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    eIF2A eukaryotic translation initiation factor 2A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF2Aprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 2Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037135
    Locus tag
    Dmel_CG7414
    See related
    AllianceGenome:FB:FBgn0037135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.243; CG7414; dEIF2A; Dmel\CG7414; EIF2A
    Summary
    Predicted to enable nucleic acid binding activity and ribosome binding activity. Predicted to be involved in regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of cytosolic small ribosomal subunit. Is expressed in adult head and organism. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF2A in Genome Data Viewer
    Location:
    78F3-78F4; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21824740..21827856)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21817840..21820956)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cyclin H Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unconventional translation initiation factor EIF2A is required for Drosophila spermatogenesis. Lowe DD, et al. Dev Dyn, 2022 Feb. PMID 34278643, Free PMC Article
    2. Non-canonical initiation factors modulate repeat-associated non-AUG translation. Green KM, et al. Hum Mol Genet, 2022 Aug 17. PMID 35220421, Free PMC Article
    3. Increased proteomic complexity in Drosophila hybrids during development. Bamberger C, et al. Sci Adv, 2018 Feb. PMID 29441361, Free PMC Article
    4. Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila. Emond-Fraser V, et al. Open Biol, 2023 Jul. PMID 37463656, Free PMC Article
    5. A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster. López Y, et al. PLoS One, 2014. PMID 25153327, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2A
    Names
    CG7414-PA
    CG7414-PC
    CG7414-PD
    CG7414-PE
    eIF2A-PA
    eIF2A-PC
    eIF2A-PD
    eIF2A-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21824740..21827856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202226.1 → NP_001189155.1  eukaryotic translation initiation factor 2A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS45
      Conserved Domains (3) summary
      pfam08662
      Location:232 → 419
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:292 → 327
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:289 → 391
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_141108.2 → NP_649365.1  eukaryotic translation initiation factor 2A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VNX8
      UniProtKB/TrEMBL
      B7Z098
      Related
      FBpp0078095
      Conserved Domains (3) summary
      pfam08662
      Location:232 → 419
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:292 → 327
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:289 → 391
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001202227.2 → NP_001189156.1  eukaryotic translation initiation factor 2A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS45
      Conserved Domains (3) summary
      pfam08662
      Location:232 → 419
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:292 → 327
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:289 → 391
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001144524.3 → NP_001137996.2  eukaryotic translation initiation factor 2A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137996.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VNX8
      UniProtKB/TrEMBL
      B7Z098
      Conserved Domains (3) summary
      pfam08662
      Location:232 → 419
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:292 → 327
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:289 → 391
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z098 B7Z098
    M9MS45 M9MS45
    Q9VNX8.1 Q9VNX8

    Gene LinkOut

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