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    Myd88 Myd88 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35956, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Myd88provided by FlyBase
    Official Full Name
    Myd88provided by FlyBase
    Primary source
    FLYBASE:FBgn0033402
    Locus tag
    Dmel_CG2078
    See related
    AllianceGenome:FB:FBgn0033402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2078; Dmel\CG2078; DmMyd88; DmMyD88; DMMYD88; dMyd88; dMyD88; dMYd88; dsMyD88; EP(2)2535; kra; Kra; LD20892; MyD8; myd88; MyD88; MYD88; Myd88F
    Summary
    Enables Toll binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and signaling adaptor activity. Involved in several processes, including Toll signaling pathway; defense response to other organism; and positive regulation of macromolecule biosynthetic process. Located in cytoplasmic side of plasma membrane. Is expressed in several structures, including anal pad primordium; embryonic anal pad; embryonic/larval midgut; embryonic/larval midgut interstitial cell; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); hepatocellular carcinoma; lung cancer (multiple); lymphoma (multiple); and primary immunodeficiency disease. Orthologous to human MYD88 (MYD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Myd88 in Genome Data Viewer
    Location:
    45C5-45C5; 2-60 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9302823..9308722, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5190328..5196227, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Component of oligomeric golgi complex 6 Neighboring gene Mitotic arrest-deficient 1 Neighboring gene DNA fragmentation factor-related protein 2 Neighboring gene long non-coding RNA:CR45918 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-987 stem loop Neighboring gene Odorant receptor 45a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Of mice, flies--and men? Comparing fungal infection models for large-scale screening efforts. Brunke S, et al. Dis Model Mech, 2015 May. PMID 25786415, Free PMC Article
    2. The relationship between the preference of mating type (MAT) and source in the opportunistic pathogen Talaromyces marneffei. Qu Q, et al. Med Mycol, 2023 Apr 3. PMID 36931899
    3. An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei. Wang X, et al. Fly (Austin), 2024 Dec. PMID 39239739, Free PMC Article
    4. Drosophila melanogaster Systemic Infection Model to Study Altered Virulence during Polymicrobial Infection by Aeromonas. Robert A, et al. Pathogens, 2023 Mar 2. PMID 36986327, Free PMC Article
    5. Dual comprehensive approach to decipher the Drosophila Toll pathway, ex vivo RNAi screenings and immunoprecipitation-mass spectrometry. Kanoh H, et al. Biochem Biophys Res Commun, 2019 Jan 1. PMID 30497778

    See all (232) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei.
      Title: An unusual Toll/MyD88-mediated Drosophila host defence against Talaromyces marneffei.
    2. a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.
      Title: A negative role for MyD88 in the resistance to starvation as revealed in an intestinal infection of Drosophila melanogaster with the Gram-positive bacterium Staphylococcus xylosus.
    3. propose that dMyD88 is the functional homolog of TIRAP and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors
      Title: Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
    4. both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle.
      Title: Assembly of oligomeric death domain complexes during Toll receptor signaling.
    5. DmMyD88 encodes an essential component of the Toll pathway in dorsoventral pattern formation.
      Title: DmMyD88 controls dorsoventral patterning of the Drosophila embryo.
    6. We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.
      Title: Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables TIR domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Toll binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Toll binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables Toll-like receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Toll signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antifungal humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antifungal peptide production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mycotoxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to tumor cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in toll-like receptor 4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Myd88
    Names
    CG2078-PA
    CG2078-PB
    CG2078-PC
    MyD88
    Myd88-PA
    Myd88-PB
    Myd88-PC
    Myd88F
    dMyD88
    krapfen

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9302823..9308722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273892.1 → NP_001260821.1  Myd88, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K105
      Conserved Domains (2) summary
      cl14633
      Location:90 → 172
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl23749
      Location:242 → 375
      TIR_2; TIR domain

    2. NM_136635.3 → NP_610479.1  Myd88, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K105
      Related
      FBpp0087679
      Conserved Domains (2) summary
      cl14633
      Location:90 → 172
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl23749
      Location:242 → 375
      TIR_2; TIR domain

    3. NM_001299317.1 → NP_001286246.1  Myd88, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K105
      Conserved Domains (2) summary
      cl14633
      Location:90 → 172
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl23749
      Location:242 → 375
      TIR_2; TIR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K105 Q7K105

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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