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    wisp wispy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wispprovided by FlyBase
    Official Full Name
    wispyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260780
    Locus tag
    Dmel_CG15737
    See related
    AllianceGenome:FB:FBgn0260780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15737; DmCG15737; Dmel\CG15737; fs(1)M19; PAP; TAMP; TUTase2; Wisp; Wispy
    Summary
    Enables poly(A) RNA polymerase activity. Involved in several processes, including mRNA metabolic process; microtubule cytoskeleton organization; and pronuclear fusion. Located in cytoplasm. Is expressed in several structures, including germline cell; ovary; and pole plasm. Orthologous to human TENT2 (terminal nucleotidyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wisp in Genome Data Viewer
    Location:
    10F4-10F4; 1-37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11893943..11899920)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11787976..11793953)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene severe impairment of CI with lengthened youth Neighboring gene Upf1 RNA helicase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenylation of maternally inherited microRNAs by Wispy. Lee M, et al. Mol Cell, 2014 Dec 4. PMID 25454948, Free PMC Article
    2. Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA. Norvell A, et al. Dev Dyn, 2015 Oct. PMID 26214278
    3. Translational control of gurken mRNA in Drosophila development. Derrick CJ, et al. Cell Cycle, 2017 Jan 2. PMID 27841697, Free PMC Article
    4. Modulating the bicoid gradient in space and time. Cai X, et al. Hereditas, 2021 Aug 17. PMID 34404481, Free PMC Article
    5. mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development. Lim J, et al. Genes Dev, 2016 Jul 15. PMID 27445395, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modulating the bicoid gradient in space and time.
      Title: Modulating the bicoid gradient in space and time.
    2. piRNAs and Aub actively protect germ cell mRNAs in the germ plasm. Aub directly interacts with the germline-specific poly(A) polymerase Wispy, thus leading to mRNA polyadenylation and stabilization in the germ plasm.
      Title: piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm.
    3. Localized cytoplasmic polyadenylation of grk mRNA by Wisp and Orb is necessary to achieve appropriate Grk protein accumulation in the D/A corner of the oocyte during mid to late oogenesis.
      Title: Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA.
    4. Results suggest that Wisp interacts with Ago1 and induces miRNA adenylation and facilitates its downregulation.
      Title: Adenylation of maternally inherited microRNAs by Wispy.
    5. Wispy regulates polyadenylation of many mRNAs in late-stage oocytes.
      Title: Cytoplasmic polyadenylation is a major mRNA regulator during oogenesis and egg activation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytosolic mRNA polyadenylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm aster formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly involved in female meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    wispy
    Names
    3' terminal uridylyl transferase 2
    CG15737-PA
    CG15737-PB
    CG15737-PC
    female sterile(1)M19
    poly(A) polymerase
    temprano
    toll pathway activation mediating protein
    wisp-PA
    wisp-PB
    wisp-PC
    NP_001285143.1
    NP_001285144.1
    NP_572766.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11893943..11899920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298215.1 → NP_001285144.1  wispy, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYS4
      UniProtKB/TrEMBL
      L7XBB9
      Conserved Domains (2) summary
      cd05402
      Location:987 → 1122
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:1211 → 1272
      PAP_assoc; Cid1 family poly A polymerase

    2. NM_132538.2 → NP_572766.1  wispy, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYS4
      UniProtKB/TrEMBL
      L7XBB9
      Related
      FBpp0073417
      Conserved Domains (2) summary
      cd05402
      Location:987 → 1122
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:1211 → 1272
      PAP_assoc; Cid1 family poly A polymerase

    3. NM_001298214.1 → NP_001285143.1  wispy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEK3
      Conserved Domains (2) summary
      cd05402
      Location:986 → 1121
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:1210 → 1271
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L7XBB9 L7XBB9
    Q9VYS4.1 Q9VYS4
    X2JEK3 X2JEK3

    Gene LinkOut

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