CSN5 COP9 signalosome subunit 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CSN5provided by FlyBase
Official Full Name: COP9 signalosome subunit 5provided by FlyBase
Primary source: FLYBASE:FBgn0027053
Locus tag: Dmel_CG14884
See related: AllianceGenome:FB:FBgn0027053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA.LD14392; BcDNA:LD14392; CG14884; CH5; CSN-5; csn5; Csn5; dch5; Dch5; DCH5; Dmel\CG14884; Jab1; JAB1; jab1/csn5; JAB1/CSN5; JadBp; l(3)89Cf; l(3)L4032; l(3)M203; Q9XZ58; quo
Summary: Enables metal-dependent deNEDDylase activity. Involved in several processes, including neurogenesis; oogenesis; and regulation of protein catabolic process. Located in cytoplasm and nuclear periphery. Part of COP9 signalosome. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89B17-89B17; 3-58 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16470099..16471406)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12295821..12297128)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation.
Title: SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation.
during oogenesis CSN5/JAB1, one subunit of the CSN, is required for meiotic progression and for establishment of both the AP and DV axes of the Drosophila oocyte
Title: CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint.
COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
Title: COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway
Title: The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.
results presented here indicate that CSN5 is a negative regulator of Dorsal subcellular localization, and of hemocyte proliferation and differentiation
Title: COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables deNEDDylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal-dependent deNEDDylase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line cyst encapsulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deneddylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: COP9 signalosome subunit 5

Names: CG14884-PA; CG14884-PB; COP9 complex homolog subunit 5; COP9 complex subunit 5; CSN5-PA; CSN5-PB; JUN activation domain-binding protein-1; Jun activation domain binding protein; drosophila COP9 signalosome homolog 5

NP_001262639.1

EC 3.4.-.-

NP_477442.1

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16470099..16471406

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058094.5 → NP_477442.1 COP9 signalosome subunit 5, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477442.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KN57, Q9UB04, Q9XZ58

Related

FBpp0082743

Conserved Domains (1) summary

cd08069
Location:41 → 305

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
NM_001275710.1 → NP_001262639.1 COP9 signalosome subunit 5, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262639.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHM2

Conserved Domains (1) summary

cd08069
Location:41 → 303

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5