Dcp-1 Death caspase-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dcp-1provided by FlyBase
Official Full Name: Death caspase-1provided by FlyBase
Primary source: FLYBASE:FBgn0010501
Locus tag: Dmel_CG5370
See related: AllianceGenome:FB:FBgn0010501
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ccp1; cDcp; cDcp-1; CG5370; dcp-1; DCp-1; DCP-1; dcp1; Dcp1; DCP1; Dmel\CG5370; l(2)01862; l(2)02132
Summary: Enables BIR domain binding activity and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Involved in several processes, including negative regulation of cell communication; neuron remodeling; and nurse cell apoptotic process. Located in mitochondrial matrix; neuronal cell body; and neuronal ribonucleoprotein granule. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; clypeo-labral primordium; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and neurodegenerative disease (multiple). Orthologous to human CASP3 (caspase 3) and CASP7 (caspase 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59E3-59E3; 2-103 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23551313..23553547)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19438836..19441070)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis.
Title: Frazzled/Dcc acts independently of Netrin to promote germline survival during Drosophila oogenesis.
drICE and dcp-1 function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE but not dcp-1, but required drICE and dcp-1 when drICE activity was reduced via hypomorphic mutation.
Title: The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
Title: Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.
Autophagy suppresses Dcp-1-mediated apoptotic cell death, whereas Dcp-1 positively regulates autophagy, possibly through feedback regulation.
Title: A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1, indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Title: piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline.
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.
Title: Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.
A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1.
Title: The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila.
novel characteristic morphological features of egg chambers lacking both dcp-1 and pita functions in the germline cells; suggested an essential role of dcp-1 and/or pita during mid-oogenesis
Title: Morphological irregularities and features of resistance to apoptosis in the dcp-1/pita double mutated egg chambers during Drosophila oogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0623 (e-PCR)
- UniSTS:50079

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables BIR domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nurse cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: death caspase-1

Names: CG5370-PA; Dcp-1-PA; caspase; caspase 1; caspase-1; death caspase 1

NP_476974.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23551313..23553547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057626.4 → NP_476974.1 death caspase-1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476974.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02002, Q9W1N0

Related

FBpp0071971

Conserved Domains (1) summary

smart00115
Location:71 → 313

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues