VhaAC45 Vacuolar H[+] ATPase AC45 accessory subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: VhaAC45provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase AC45 accessory subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0262515
Locus tag: Dmel_CG8029
See related: AllianceGenome:FB:FBgn0262515
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.117; ATP6AP1; CG8029; Dmel\CG8029; l(2)SH1634; l(2)SH2 1634; vhaAC45
Summary: Predicted to enable ATPase activator activity. Involved in vacuolar proton-transporting V-type ATPase complex assembly. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; larval muscle system; and midgut. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to several human genes including ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9207561..9209774)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5095066..5097279)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of cellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar proton-transporting V-type ATPase complex assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase complex	IMP Inferred from Mutant Phenotype more info	PubMed

Names: CG8029-PA; CG8029-PB; VhaAC45-PA; VhaAC45-PB; lethal (2) SH1634; vacuolar H[+] ATPase accessory protein AC45

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The following sections contain reference sequences that belong to a specific genome build. Explain