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    ear ENL/AF9-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44451, updated on 17-Dec-2024

    Summary

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    Official Symbol
    earprovided by FlyBase
    Official Full Name
    ENL/AF9-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026441
    Locus tag
    Dmel_CG4913
    See related
    AllianceGenome:FB:FBgn0026441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4913; dENL/AF9; Dmel\CG4913; Ear; ENL; ENL/AF-9; ENL/AF9; TFIIF
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling; regulation of transcription by RNA polymerase II; and transcription initiation at RNA polymerase II promoter. Part of super elongation complex. Is expressed in organism. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit) and MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ear in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15320756..15325279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11146478..11151001)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene easter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The H3K79me3 methyl-transferase Grappa is involved in the establishment and thermal plasticity of abdominal pigmentation in Drosophila melanogaster females. Narbey R, et al. Sci Rep, 2024 Apr 25. PMID 38664546, Free PMC Article
    2. Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases. Yeewa R, et al. Cell Mol Life Sci, 2022 Mar 12. PMID 35279775, Free PMC Article
    3. The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae. Johannessen JA, et al. iScience, 2023 Oct 20. PMID 37720104, Free PMC Article
    4. The histone acylation reader ENL/AF9 regulates aging in Drosophila melanogaster. Yeewa R, et al. Neurobiol Aging, 2024 Dec. PMID 39405796
    5. Transcript level is a key factor affecting RNAi efficiency. Chen J, et al. Pestic Biochem Physiol, 2021 Jul. PMID 34119217

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of super elongation complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ENL/AF9-related
    Names
    CG4913-PA
    CG4913-PB
    CG4913-PC
    ear-PA
    ear-PB
    ear-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15320756..15325279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275667.1 → NP_001262596.1  ENL/AF9-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHH1, Q9VF92
      Conserved Domains (1) summary
      pfam03366
      Location:27 → 107
      YEATS; YEATS family

    2. NM_143722.3 → NP_651979.1  ENL/AF9-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHH1, Q9VF92
      Related
      FBpp0082538
      Conserved Domains (1) summary
      pfam03366
      Location:27 → 107
      YEATS; YEATS family

    3. NM_001275666.1 → NP_001262595.1  ENL/AF9-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG69, Q8IHH1
      Conserved Domains (1) summary
      pfam03366
      Location:27 → 107
      YEATS; YEATS family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG69 A0A0B4KG69
    Q8IHH1 Q8IHH1
    Q8MRJ5 Q8MRJ5
    Q9VF92 Q9VF92

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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