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    Xxylt Xyloside xylosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37833, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xxyltprovided by FlyBase
    Official Full Name
    Xyloside xylosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034959
    Locus tag
    Dmel_CG11388
    See related
    AllianceGenome:FB:FBgn0034959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey287; CG11388; dibeta3GnT6; Dmel\CG11388; XxylT
    Summary
    Enables xylosyl alpha-1,3-xylosyltransferase activity. Involved in negative regulation of Notch signaling pathway and protein O-linked glycosylation. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human XXYLT1 (xyloside xylosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Xxylt in Genome Data Viewer
    Location:
    60B4-60B4; 2-106 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24022343..24023981)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19909866..19911504)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Radial spoke head protein 4a Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45350 Neighboring gene Adenylate kinase 2 Neighboring gene Ejaculatory bulb protein III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of notch signaling by xylose. Lee TV, et al. PLoS Genet, 2013 Jun. PMID 23754965, Free PMC Article
    2. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. Harvey BM, et al. J Biol Chem, 2016 Jul 29. PMID 27268051, Free PMC Article
    3. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Pandey A, et al. Glycobiology, 2018 Nov 1. PMID 30169771, Free PMC Article
    4. O-Linked glycosylation in Drosophila melanogaster. Zhang L, et al. Curr Opin Struct Biol, 2019 Jun. PMID 30852302, Free PMC Article
    5. Synthesis and biological roles of O-glycans in insects. Li W, et al. Glycoconj J, 2020 Feb. PMID 30937676

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-xylosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xylosyl alpha-1,3-xylosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xylosyl alpha-1,3-xylosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in O-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    xyloside xylosyltransferase
    Names
    CG11388-PA
    Xxylt-PA
    NP_611871.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24022343..24023981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138027.3 → NP_611871.2  xyloside xylosyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611871.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SJ1, Q9W1D1
      Related
      FBpp0072071
      Conserved Domains (1) summary
      cl11394
      Location:172 → 422
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SJ1 Q95SJ1
    Q9W1D1 Q9W1D1

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