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    GstZ2 Glutathione S transferase Z2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41133, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GstZ2provided by FlyBase
    Official Full Name
    Glutathione S transferase Z2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037697
    Locus tag
    Dmel_CG9363
    See related
    AllianceGenome:FB:FBgn0037697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg9363; CG9363; Dmel\CG9363; gstz2; gstZ2; GSTZ2
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrial matrix. Is expressed in adult head. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstZ2 in Genome Data Viewer
    Location:
    85D17-85D17; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9456815..9460652, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5282537..5286374, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pasilla Neighboring gene Glutathione S transferase Z1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45203 Neighboring gene phurba tashi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioral and Transcriptional Response to Selection for Olfactory Behavior in Drosophila. Brown EB, et al. G3 (Bethesda), 2020 Apr 9. PMID 32024668, Free PMC Article
    2. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
    3. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
    4. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article
    5. Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. Marco A, et al. Mol Biol Evol, 2004 Jan. PMID 14595091

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables maleylacetoacetate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables maleylacetoacetate isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase Z2
    Names
    CG9363-PA
    CG9363-PB
    CG9363-PC
    GstZ2-PA
    GstZ2-PB
    GstZ2-PC
    NP_649895.1
    NP_731358.1
    NP_996190.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9456815..9460652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169286.2 → NP_731358.1  glutathione S transferase Z2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHD2
      Related
      FBpp0081519
      Conserved Domains (1) summary
      TIGR01262
      Location:10 → 214
      maiA; maleylacetoacetate isomerase

    2. NM_206468.2 → NP_996190.1  glutathione S transferase Z2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996190.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHD2
      Conserved Domains (1) summary
      TIGR01262
      Location:5 → 209
      maiA; maleylacetoacetate isomerase

    3. NM_141638.3 → NP_649895.1  glutathione S transferase Z2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649895.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H0RNF8, H8F4P9, Q8INN9, Q9VHD2
      Related
      FBpp0081520
      Conserved Domains (3) summary
      cd03191
      Location:104 → 217
      GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
      cd03042
      Location:16 → 90
      GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      TIGR01262
      Location:17 → 221
      maiA; maleylacetoacetate isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHD2.1 Q9VHD2

    Gene LinkOut

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