Hr96 Hormone receptor-like in 96 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hr96provided by FlyBase
Official Full Name: Hormone receptor-like in 96provided by FlyBase
Primary source: FLYBASE:FBgn0015240
Locus tag: Dmel_CG11783
See related: AllianceGenome:FB:FBgn0015240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11783; dHR96; Dhr96; DHR96; Dmel\CG11783; HR96; NR1J1
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cholesterol homeostasis; regulation of transcription by RNA polymerase II; and triglyceride homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval Malpighian tubule; embryonic/larval fat body; embryonic/larval proventriculus; embryonic/larval salivary gland; and gastric caecum. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to several human genes including NR1I2 (nuclear receptor subfamily 1 group I member 2) and VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96B16-96B17; 3-86 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25025235..25029351)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20850957..20855073)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila.
Title: Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila.
identified a nuclear hormone receptor, DHR96, as an essential mediator of the increased xenobiotic resistance of IIS mutant flies. However, the IIS mutants remained long-lived in the absence of DHR96 and the xenobiotic resistance that it conferred.
Title: Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila.
DHR96 coordinates lipid metabolism through direct regulation of LipA homolog magro proteins.
Title: Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro.
DHR96 function is required in the midgut for the breakdown of dietary fat
Title: The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.
DHR96 is activated when cellular cholesterol concentrations drop below a critical threshold in order to protect cells from severe cholesterol deprivation.
Title: Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1624 (e-PCR)
- UniSTS:82724

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hormone receptor-like in 96

Names: CG11783-PA; Hr96-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25025235..25029351

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079769.3 → NP_524493.1 hormone receptor-like in 96 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524493.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24143, Q9VBZ7

Related

FBpp0084131

Conserved Domains (3) summary

cd06929
Location:523 → 702

NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1

cd06966
Location:5 → 98

NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers

cl11397
Location:462 → 573

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators