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    CG5687 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5687provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035293
    Locus tag
    Dmel_CG5687
    See related
    AllianceGenome:FB:FBgn0035293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey42; Dmel\CG5687; dSLC5A2
    Summary
    Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5687 in Genome Data Viewer
    Location:
    62B11-62B11; 3-1.0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1933633..1939103, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1933633..1939103, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Cysteine-GCA 2-1 Neighboring gene Dbx Neighboring gene long non-coding RNA:CR45826 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44536 Neighboring gene Microfibril-associated protein 1 Neighboring gene mutator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells. Yildirim K, et al. Biol Open, 2022 Jan 15. PMID 34897385, Free PMC Article
    2. A novel post-developmental role of the Hox genes underlies normal adult behavior. Raouf Issa A, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36454751, Free PMC Article
    3. Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila. Dus M, et al. Nat Neurosci, 2013 May. PMID 23542692, Free PMC Article
    4. RNA degradation is required for the germ-cell to maternal transition in Drosophila. Blatt P, et al. Curr Biol, 2021 Jul 26. PMID 33989522, Free PMC Article
    5. Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. VoSSfeldt H, et al. PLoS One, 2012. PMID 23139745, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5687-PA
    CG5687-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1933633..1939103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299981.1 → NP_001286910.1  uncharacterized protein Dmel_CG5687, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961Q9, Q9W063
      Conserved Domains (1) summary
      cd11492
      Location:99 → 620
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain

    2. NM_139421.4 → NP_647678.3  uncharacterized protein Dmel_CG5687, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647678.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961Q9, Q9W063
      Related
      FBpp0072737
      Conserved Domains (1) summary
      cd11492
      Location:99 → 620
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961Q9 Q961Q9

    Gene LinkOut

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