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    SCOT Succinyl-CoA:3-ketoacid CoA transferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCOTprovided by FlyBase
    Official Full Name
    Succinyl-CoA:3-ketoacid CoA transferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035298
    Locus tag
    Dmel_CG1140
    See related
    AllianceGenome:FB:FBgn0035298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH54340; cDNA B; CG1140; CT1116; Dmel\CG1140; DmSCOT
    Summary
    Enables succinyl-CoA:3-oxo-acid CoA-transferase activity. Predicted to be involved in cellular ketone body metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and mesoderm. Orthologous to several human genes including OXCT2 (3-oxoacid CoA-transferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SCOT in Genome Data Viewer
    Location:
    62B11-62B12; 3-1.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1963143..1966805)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1963143..1966805)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Microfibril-associated protein 1 Neighboring gene mutator 2 Neighboring gene Centrobin Neighboring gene mauve Neighboring gene antisense RNA:CR45827 Neighboring gene antisense RNA:CR45828 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene arcus

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. Zhang M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Oct. PMID 24100554, Free PMC Article
    2. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster. Kasravi A, et al. Genetics, 1999 Jul. PMID 10388821, Free PMC Article
    3. Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. Celotto AM, et al. PLoS One, 2011. PMID 21991365, Free PMC Article
    4. Dietary fiber supplementation increases Drosophila melanogaster lifespan and gut microbiota diversity. Beghelli D, et al. Food Funct, 2024 Jul 15. PMID 38912918
    5. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Teleman AA, et al. Cell Metab, 2008 Jan. PMID 18177722

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The crystal structure of DmSCOT was determined at 2.64 A resolution.
      Title: Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CoA-transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinyl-CoA:3-oxo-acid CoA-transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinyl-CoA:3-oxo-acid CoA-transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinyl-CoA:3-oxo-acid CoA-transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ketone body catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ketone body metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ketone body metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Succinyl-CoA:3-ketoacid CoA transferase
    Names
    3-oxoacid CoA-transferase
    3-oxoacid-CoA transferase
    3-oxoacid-CoA-transferase
    CG1140-PA
    CG1140-PB
    CG1140-PC
    SCOT-PA
    SCOT-PB
    SCOT-PC
    citric acid synthetase
    NP_001261301.1
    NP_647683.1
    NP_728699.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1963143..1966805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167928.2 → NP_728699.1  Succinyl-CoA:3-ketoacid CoA transferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV34
      Related
      FBpp0072722
      Conserved Domains (3) summary
      TIGR02428
      Location:284 → 490
      pcaJ_scoB_fam; 3-oxoacid CoA-transferase, B subunit
      COG1788
      Location:21 → 254
      AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
      COG4670
      Location:25 → 497
      YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]

    2. NM_001274372.1 → NP_001261301.1  Succinyl-CoA:3-ketoacid CoA transferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV34, M9PGX7
      Conserved Domains (2) summary
      TIGR02428
      Location:232 → 438
      pcaJ_scoB_fam; 3-oxoacid CoA-transferase, B subunit
      COG1788
      Location:2 → 202
      AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

    3. NM_139426.3 → NP_647683.1  Succinyl-CoA:3-ketoacid CoA transferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRG3, Q9W058
      UniProtKB/TrEMBL
      C8VV34
      Related
      FBpp0072723
      Conserved Domains (2) summary
      TIGR02428
      Location:298 → 504
      pcaJ_scoB_fam; 3-oxoacid CoA-transferase, B subunit
      COG1788
      Location:35 → 268
      AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGX7 M9PGX7
    Q8IGC8 Q8IGC8
    Q9W058.1 Q9W058

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