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    Ac3 Adenylate cyclase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35419, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ac3provided by FlyBase
    Official Full Name
    Adenylate cyclase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0023416
    Locus tag
    Dmel_CG1506
    See related
    AllianceGenome:FB:FBgn0023416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 3; ac3; AC3; CG1506; DAC3; DAC39E; dADCY3; Dmel\CG1506
    Summary
    Enables adenylate cyclase activity. Involved in locomotor rhythm. Predicted to be active in plasma membrane. Is expressed in adult brain; adult head; adult optic lobe neurons; antenna; and gnathal ganglion. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ac3 in Genome Data Viewer
    Location:
    39E3-39E3; 2-54 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21632587..21647964)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21632587..21647964)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43148 Neighboring gene long non-coding RNA:CR44993 Neighboring gene Decondensation factor 31 Neighboring gene long non-coding RNA:CR43144 Neighboring gene Cullin 2

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    mobile_element

    • Loc: 21644393-21644993 mobile_element_type = transposon:INE-1{}4741
    • Loc: 21644994-21645053 mobile_element_type = transposon:FB{}4835
    • Loc: 21646497-21646546 mobile_element_type = transposon:INE-1{}4742

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity  
    enables adenylate cyclase activity PubMed 
    enables adenylate cyclase activity  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in cAMP biosynthetic process  
    involved_in cAMP biosynthetic process  
    involved_in circadian rhythm PubMed 
    involved_in intracellular signal transduction  
    involved_in locomotor rhythm PubMed 
    Component Evidence Code Pubs
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    adenylate cyclase 3
    Names
    Ac3-PA
    Ac3-PC
    CG1506-PA
    CG1506-PC
    NP_001014496.1
    NP_610116.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21632587..21647964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136272.3 → NP_610116.2  adenylate cyclase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610116.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96306, Q9V9R3
      Related
      FBpp0085252
      Conserved Domains (3) summary
      smart00044
      Location:256 → 453
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:892 → 1092
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:127 → 285
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    2. NM_001014496.3 → NP_001014496.1  adenylate cyclase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RI9
      Conserved Domains (1) summary
      pfam16214
      Location:127 → 285
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
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