U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG31368 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41437, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG31368provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051368
    Locus tag
    Dmel_CG31368
    See related
    AllianceGenome:FB:FBgn0051368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14729; CG14730; Dmel\CG31368; Salsa
    Summary
    Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of Prp19 complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval nervous system. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG31368 in Genome Data Viewer
    Location:
    87A1-87A1; 3-51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11882790..11892382)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7708512..7718104)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shadow Neighboring gene methuselah-like 5 Neighboring gene Dynein axonemal light intermediate chain 1 Neighboring gene Cadherin 87A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning. Patel MV, et al. Dev Biol, 2016 Jun 1. PMID 26994946, Free PMC Article
    2. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, et al. Genes Dev, 2013 Feb 15. PMID 23392610, Free PMC Article
    3. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Liu J, et al. Science, 2009 Feb 27. PMID 19164706, Free PMC Article
    4. NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal-ventral patterning. Rathore OS, et al. RNA, 2020 Dec. PMID 32963109, Free PMC Article
    5. Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. Guilgur LG, et al. Elife, 2014 Apr 22. PMID 24755291, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG31368-PC
    CG31368-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11882790..11892382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206476.3 → NP_996198.2  uncharacterized protein Dmel_CG31368, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996198.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSN8
      Conserved Domains (5) summary
      COG1112
      Location:1012 → 1348
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam13086
      Location:818 → 1123
      AAA_11; AAA domain
      pfam13245
      Location:821 → 893
      AAA_19; Part of AAA domain
      pfam16399
      Location:33 → 815
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:1131 → 1321
      UvrD_C_2; UvrD-like helicase C-terminal domain

    2. NM_169439.4 → NP_731647.3  uncharacterized protein Dmel_CG31368, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731647.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU45, Q9VGG9
      Conserved Domains (5) summary
      COG1112
      Location:1012 → 1337
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam13086
      Location:818 → 1123
      AAA_11; AAA domain
      pfam13245
      Location:821 → 893
      AAA_19; Part of AAA domain
      pfam16399
      Location:33 → 815
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:1131 → 1321
      UvrD_C_2; UvrD-like helicase C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KSN8 Q7KSN8
    Q8MQK8 Q8MQK8
    Q8MSA2 Q8MSA2
    Q9VGG9 Q9VGG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous