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    Dic4 Dicarboxylate carrier 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dic4provided by FlyBase
    Official Full Name
    Dicarboxylate carrier 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0036808
    Locus tag
    Dmel_CG18363
    See related
    AllianceGenome:FB:FBgn0036808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18363; DmDic4p; Dmel\CG18363
    Summary
    Predicted to enable antiporter activity; sulfate transmembrane transporter activity; and thiosulfate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport; sulfate transmembrane transport; and thiosulfate transport. Located in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dic4 in Genome Data Viewer
    Location:
    75D6-75D6; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18696402..18698412, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18689502..18691512, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43987 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44674 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel subfamily of mitochondrial dicarboxylate carriers from Drosophila melanogaster: biochemical and computational studies. Iacopetta D, et al. Biochim Biophys Acta, 2011 Mar. PMID 21130726
    2. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
    3. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
    4. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Junion G, et al. Genes Dev, 2007 Dec 1. PMID 18056427, Free PMC Article
    5. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables dicarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in dicarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dicarboxylate carrier 4
    Names
    CG18363-PA
    CG18363-PB
    CG18363-PC
    Dic4-PA
    Dic4-PB
    Dic4-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18696402..18698412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275092.1 → NP_001262021.1  dicarboxylate carrier 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262021.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVS1
      Conserved Domains (2) summary
      PTZ00169
      Location:26 → 288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:104 → 201
      Mito_carr; Mitochondrial carrier protein

    2. NM_001275091.2 → NP_001262020.1  dicarboxylate carrier 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFM0
      Conserved Domains (1) summary
      pfam00153
      Location:26 → 100
      Mito_carr; Mitochondrial carrier protein

    3. NM_140797.3 → NP_649054.1  dicarboxylate carrier 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVS1
      Related
      FBpp0074857
      Conserved Domains (2) summary
      PTZ00169
      Location:26 → 288
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:104 → 201
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFM0 M9PFM0
    Q9VVS1 Q9VVS1

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