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    Sec63 Secretory 63 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec63provided by FlyBase
    Official Full Name
    Secretory 63provided by FlyBase
    Primary source
    FLYBASE:FBgn0035771
    Locus tag
    Dmel_CG8583
    See related
    AllianceGenome:FB:FBgn0035771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.333; CG8583; Dmel\CG8583; peg; sec63
    Summary
    Predicted to enable protein transmembrane transporter activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane and post-translational protein targeting to endoplasmic reticulum membrane. Located in fusome. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic hypopharynx; embryonic/larval salivary gland; and gut section. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec63 in Genome Data Viewer
    Location:
    65F7-65F7; 3-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7360561..7364366)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7353661..7357466)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45822 Neighboring gene CTCF Neighboring gene pastrel Neighboring gene antisense RNA:CR45835 Neighboring gene Sh3beta Neighboring gene akirin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Hox gene Abd-B controls stem cell niche function in the Drosophila testis. Papagiannouli F, et al. Dev Cell, 2014 Jan 27. PMID 24480643
    2. Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B. Papagiannouli F, et al. Comput Struct Biotechnol J, 2015. PMID 25750700, Free PMC Article
    3. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
    4. The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. Mohan M, et al. EMBO J, 2007 Oct 3. PMID 17805343, Free PMC Article
    5. Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons. Chung CG, et al. Cell Rep, 2017 Jul 11. PMID 28700938

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 63
    Names
    CG8583-PA
    Sec63 ortholog
    Sec63-PA
    sec63

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7360561..7364366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139854.2 → NP_648111.1  secretory 63 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VS57
      Related
      FBpp0076558
      Conserved Domains (3) summary
      smart00611
      Location:211 → 709
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:105 → 164
      DnaJ; DnaJ domain
      pfam14797
      Location:559 → 626
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS57 Q9VS57

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