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    CG2852 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2852provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034753
    Locus tag
    Dmel_CG2852
    See related
    AllianceGenome:FB:FBgn0034753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2852
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 9. Orthologous to several human genes including PPIB (peptidylprolyl isomerase B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2852 in Genome Data Viewer
    Location:
    58F3-58F3; 2-100 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22644646..22646344, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18532151..18533849, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S24 Neighboring gene UDP-glycosyltransferase family 317 member A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article
    2. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article
    3. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047
    4. DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells. Tarayrah-Ibraheim L, et al. Nat Commun, 2021 Apr 16. PMID 33863891, Free PMC Article
    5. Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Hoffmann J, et al. Aging (Albany NY), 2013 Apr. PMID 23765091, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2852-PA
    CG2852-PD
    NP_611695.1
    NP_726217.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22644646..22646344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166539.2 → NP_726217.2  uncharacterized protein Dmel_CG2852, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726217.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W227
      Conserved Domains (1) summary
      cl00197
      Location:30 → 188
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

    2. NM_137851.4 → NP_611695.1  uncharacterized protein Dmel_CG2852, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W227
      Related
      FBpp0071844
      Conserved Domains (1) summary
      cl00197
      Location:30 → 188
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W227 Q9W227

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