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    CG17575 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17575provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250842
    Locus tag
    Dmel_CG17575
    See related
    AllianceGenome:FB:FBgn0250842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-SAGE:Wang-113; Dmel\CG17575
    Summary
    Involved in protein localization; regulation of female receptivity, post-mating; and sperm competition. Located in extracellular space. Is expressed in several structures, including adult head; adult hemolymph; female reproductive system; oviduct; and uterus. Orthologous to human R3HDML (R3H domain containing like) and PI15 (peptidase inhibitor 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17575 in Genome Data Viewer
    Location:
    49D4-49D4; 2-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12845544..12846596, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8733049..8734101, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 9h1 Neighboring gene Odorant receptor 49b Neighboring gene antares Neighboring gene antisense RNA:CR45468 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sex peptide is required for the efficient release of stored sperm in mated Drosophila females. Avila FW, et al. Genetics, 2010 Oct. PMID 20679516, Free PMC Article
    2. A network of interactions among seminal proteins underlies the long-term postmating response in Drosophila. Ram KR, et al. Proc Natl Acad Sci U S A, 2009 Sep 8. PMID 19706411, Free PMC Article
    3. Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females. Misra S, et al. Elife, 2020 Jul 16. PMID 32672537, Free PMC Article
    4. Acp36DE is required for uterine conformational changes in mated Drosophila females. Avila FW, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19805225, Free PMC Article
    5. Long-term interaction between Drosophila sperm and sex peptide is mediated by other seminal proteins that bind only transiently to sperm. Singh A, et al. Insect Biochem Mol Biol, 2018 Nov. PMID 30217614, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in multicellular organismal reproductive process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in sperm competition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17575-PA
    CG17575-PB
    anon-SAGE:Wang-113

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12845544..12846596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136977.2 → NP_610821.1  uncharacterized protein Dmel_CG17575, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z957, Q8T499
      Related
      FBpp0086932, FBtr0087819
      Conserved Domains (1) summary
      cd05380
      Location:64 → 243
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

    2. NM_001201988.1 → NP_001188917.1  uncharacterized protein Dmel_CG17575, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188917.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCT2, Q8T499
      Conserved Domains (1) summary
      cd05380
      Location:64 → 250
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCT2 A0A0B4JCT2
    A1Z957 A1Z957
    Q8T499 Q8T499

    Gene LinkOut

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