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    Caf1-105 Chromatin assembly factor 1, p105 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36107, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Caf1-105provided by FlyBase
    Official Full Name
    Chromatin assembly factor 1, p105 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033526
    Locus tag
    Dmel_CG12892
    See related
    AllianceGenome:FB:FBgn0033526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAF p105; CAF-1 p105; Caf-105; Caf1; CAF1; Caf1-10; caf1-105; CAF1-105; Caf1-p105; CAF1-p105; CAF1-p75; CAF1-p75/p105; CAF105/75; CAF1p105; CAF1p75; CG12892; dCAF-1-p105; dCAF1-p105; dCAF1-p75; Dmel\CG12892; p105; P105; p105/p75; p75; p75/p105
    Summary
    Predicted to contribute to histone binding activity. Involved in nucleosome assembly. Part of CAF-1 complex. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Caf1-105 in Genome Data Viewer
    Location:
    47A9-47A9; 2-62 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10466001..10468540, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6353506..6356045, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1 Neighboring gene uncharacterized protein Neighboring gene withered Neighboring gene antisense RNA:CR45134

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional Regulators Compete with Nucleosomes Post-replication. Ramachandran S, et al. Cell, 2016 Apr 21. PMID 27062929, Free PMC Article
    2. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Tyler JK, et al. Mol Cell Biol, 1996 Nov. PMID 8887645, Free PMC Article
    3. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Tyler JK, et al. Mol Cell Biol, 2001 Oct. PMID 11533245, Free PMC Article
    4. Maintenance of Heterochromatin by the Large Subunit of the CAF-1 Replication-Coupled Histone Chaperone Requires Its Interaction with HP1a Through a Conserved Motif. Roelens B, et al. Genetics, 2017 Jan. PMID 27838630, Free PMC Article
    5. Epigenetic Regulation of Notch Signaling During Drosophila Development. Wei C, et al. Adv Exp Med Biol, 2020. PMID 32060871

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
      Title: Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to histone binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chromatin assembly factor 1, p105 subunit
    Names
    CG12892-PA
    Caf1-105-PA
    medium subunit of CAF-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10466001..10468540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136745.5 → NP_610589.2  chromatin assembly factor 1, p105 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610589.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z898, S5MJB4
      Related
      FBpp0087402
      Conserved Domains (3) summary
      COG2319
      Location:67 → 446
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:75 → 131
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:13 → 377
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z898 A1Z898
    Q9BII5 Q9BII5

    Gene LinkOut

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