Gmeb2 glucocorticoid modulatory element binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gmeb2provided by MGI
Official Full Name: glucocorticoid modulatory element binding protein 2provided by MGI
Primary source: MGI:MGI:2652836
See related: Ensembl:ENSMUSG00000038705 AllianceGenome:MGI:2652836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in 1st branchial arch and heart. Orthologous to human GMEB2 (glucocorticoid modulatory element binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 14.6), colon adult (RPKM 10.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.63 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180893240..180933481, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (181251449..181288106, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC102812P1 (e-PCR)
- UniSTS:270094

D2Mit457 (e-PCR), detects polymorphism
- UniSTS:129370

AI839884 (e-PCR)
- UniSTS:164198

NoName (e-PCR)
- UniSTS:234633

17.MMHAP67FRF8.seq (e-PCR)
- UniSTS:123351

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glucocorticoid modulatory element-binding protein 2

Names: GMEB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419396.1 → NP_001406325.1 glucocorticoid modulatory element-binding protein 2

Status: VALIDATED

Source sequence(s)

AL845506

UniProtKB/Swiss-Prot

P58929, Q6PCY0
NM_001419397.1 → NP_001406326.1 glucocorticoid modulatory element-binding protein 2

Status: VALIDATED

Source sequence(s)

AL845506

UniProtKB/Swiss-Prot

P58929, Q6PCY0
NM_198169.3 → NP_937812.1 glucocorticoid modulatory element-binding protein 2

See identical proteins and their annotated locations for NP_937812.1

Status: VALIDATED

Source sequence(s)

AL845506

Consensus CDS

CCDS17206.1

UniProtKB/Swiss-Prot

P58929, Q6PCY0

Related

ENSMUSP00000037075.7, ENSMUST00000049032.13

Conserved Domains (1) summary

smart00258
Location:90 → 163

SAND; SAND domain