Dgk Diacyl glycerol kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dgkprovided by FlyBase
Official Full Name: Diacyl glycerol kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0085390
Locus tag: Dmel_CG34361
See related: AllianceGenome:FB:FBgn0085390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12820; CG1535; CG18654; CG34361; DAGK; dDGK; dgk; DGK; DGKb; Dmel\CG34361
Old locus tag: CG12820; CG18654; Dmel_CG12820; Dmel_CG18654
Summary: Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to be active in plasma membrane. Is expressed in several structures, including epithelial tube; ganglia; indirect flight muscle cell; larval midline neurons; and sensory nervous system primordium. Used to study glucose metabolism disease. Orthologous to several human genes including DGKB (diacylglycerol kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43E18-43F1; 2-57 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7834812..7885982, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3722317..3773487, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c7873962-7869244 mobile_element_type = transposon:Doc{}772

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent diacylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: diacyl glycerol kinase

Names: CG34361-PE; CG34361-PF; CG34361-PG; CG34361-PH; CG34361-PI; CG34361-PJ; CG34361-PK; Dgk-PE; Dgk-PF; Dgk-PG; Dgk-PH; Dgk-PI; Dgk-PJ; Dgk-PK; diacylglycerol kinase

NP_001097219.1

EC 2.7.1.107

NP_001097220.1

EC 2.7.1.107

NP_001260792.1

EC 2.7.1.107

NP_001303337.1

EC 2.7.1.107

NP_523654.2

EC 2.7.1.107

NP_724619.2

EC 2.7.1.107

NP_995775.2

EC 2.7.1.107

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7834812..7885982 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165568.3 → NP_724619.2 diacyl glycerol kinase, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724619.2

Status: REVIEWED

Conserved Domains (7) summary

smart00045
Location:1003 → 1194

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:573 → 694

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:410 → 459

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:317 → 386

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:477 → 528

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:318 → 382

EF-hand_7; EF-hand domain pair

pfam14513
Location:9 → 313

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_001273863.1 → NP_001260792.1 diacyl glycerol kinase, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260792.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEG4

Conserved Domains (7) summary

smart00045
Location:873 → 1064

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:443 → 564

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:280 → 329

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:187 → 256

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:347 → 398

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:188 → 252

EF-hand_7; EF-hand domain pair

pfam14513
Location:9 → 183

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_001316408.1 → NP_001303337.1 diacyl glycerol kinase, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUN0

Conserved Domains (7) summary

smart00045
Location:873 → 1064

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:443 → 564

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:280 → 329

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:187 → 256

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:347 → 398

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:188 → 252

EF-hand_7; EF-hand domain pair

pfam14513
Location:9 → 183

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_001103750.3 → NP_001097220.1 diacyl glycerol kinase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097220.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q01583

Conserved Domains (7) summary

smart00045
Location:881 → 1072

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:451 → 572

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:280 → 329

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:187 → 256

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:347 → 398

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:188 → 252

EF-hand_7; EF-hand domain pair

pfam14513
Location:9 → 183

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_078930.4 → NP_523654.2 diacyl glycerol kinase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523654.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q01583

Related

FBpp0111491

Conserved Domains (2) summary

smart00045
Location:564 → 755

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:134 → 255

DAGKc; Diacylglycerol kinase catalytic domain (presumed)
NM_001103749.2 → NP_001097219.1 diacyl glycerol kinase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097219.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8DY60, A8DY61, Q01583, Q53YF9, Q7KQR7, Q8MKP0, Q9V327

Conserved Domains (7) summary

smart00045
Location:984 → 1175

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:554 → 675

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:383 → 432

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00051
Location:290 → 359

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:450 → 501

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:291 → 355

EF-hand_7; EF-hand domain pair

pfam14513
Location:9 → 286

DAG_kinase_N; Diacylglycerol kinase N-terminus
NM_206053.2 → NP_995775.2 diacyl glycerol kinase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995775.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q01583

Conserved Domains (2) summary

smart00045
Location:520 → 711

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:90 → 211

DAGKc; Diacylglycerol kinase catalytic domain (presumed)