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    Nse4 Non-SMC element 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nse4provided by FlyBase
    Official Full Name
    Non-SMC element 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032251
    Locus tag
    Dmel_CG13142
    See related
    AllianceGenome:FB:FBgn0032251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13142; Dmel\CG13142
    Summary
    Predicted to be involved in DNA repair. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human EID3 (EP300 interacting inhibitor of differentiation 3) and NSMCE4A (NSE4 homolog A, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nse4 in Genome Data Viewer
    Location:
    31E2-31E2; 2-42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10439440..10441047)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10439440..10441047)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hole-in-one Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene long non-coding RNA:CR45375 Neighboring gene lonely heart

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. Li X, et al. PLoS One, 2013. PMID 23555814, Free PMC Article
    2. Condensins: universal organizers of chromosomes with diverse functions. Hirano T. Genes Dev, 2012 Aug 1. PMID 22855829, Free PMC Article
    3. The maintenance of chromosome structure: positioning and functioning of SMC complexes. Jeppsson K, et al. Nat Rev Mol Cell Biol, 2014 Sep. PMID 25145851
    4. The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. Svetec N, et al. PLoS Genet, 2016 Mar. PMID 26950216, Free PMC Article
    5. p53 directs focused genomic responses in Drosophila. Akdemir F, et al. Oncogene, 2007 Aug 9. PMID 17310982

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Non-SMC element 4
    Names
    CG13142-PB
    CG13142-PC
    Nse4-PB
    Nse4-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10439440..10441047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135561.3 → NP_609405.2  Non-SMC element 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609405.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQ24, Q4QQ37, Q9VKV4
      Conserved Domains (1) summary
      pfam08743
      Location:200 → 282
      Nse4_C; Nse4 C-terminal

    2. NM_001169467.1 → NP_001162938.1  Non-SMC element 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162938.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQ24, Q4QQ37, Q9VKV4
      Conserved Domains (1) summary
      pfam08743
      Location:200 → 282
      Nse4_C; Nse4 C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKV4 Q9VKV4

    Gene LinkOut

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