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    TwdlE TweedleE [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TwdlEprovided by FlyBase
    Official Full Name
    TweedleEprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031957
    Locus tag
    Dmel_CG14534
    See related
    AllianceGenome:FB:FBgn0031957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14534; Dmel\CG14534
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic head epidermis; embryonic maxillary sensory complex; and ventral sensory complex primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TwdlE in Genome Data Viewer
    Location:
    28D2-28D2; 2-29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7857957..7860839, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7857957..7860839, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lectin-28C Neighboring gene Proctolin Neighboring gene long non-coding RNA:CR45364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. Guan X, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075064, Free PMC Article
    2. Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequences. Rebeiz M, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21593416, Free PMC Article
    3. Functional analysis of genes differentially expressed in the Drosophila wing disc: role of transcripts enriched in the wing region. Jacobsen TL, et al. Genetics, 2006 Dec. PMID 17028348, Free PMC Article
    4. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article
    5. Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. Garelli A, et al. Science, 2012 May 4. PMID 22556250

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TweedleE
    Names
    CG14534-PA
    TwdlE-PA
    tweedle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7857957..7860839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135313.3 → NP_609157.3  TweedleE [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609157.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZP2, Q9VLW0
      Related
      FBpp0079185
      Conserved Domains (1) summary
      smart00690
      Location:59 → 158
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZP2 Q8SZP2

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