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    Luc7l Luc7-like [ Mus musculus (house mouse) ]

    Gene ID: 66978, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Luc7lprovided by MGI
    Official Full Name
    Luc7-likeprovided by MGI
    Primary source
    MGI:MGI:1914228
    See related
    Ensembl:ENSMUSG00000024188 AllianceGenome:MGI:1914228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810045C04Rik; 2410018D03Rik
    Summary
    Enables RS domain binding activity. Acts upstream of or within negative regulation of striated muscle tissue development. Predicted to be part of U1 snRNP and U2-type prespliceosome. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human LUC7L (LUC7 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 20.3), CNS E14 (RPKM 19.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Luc7l in Genome Data Viewer
    Location:
    17 A3.3; 17 13.09 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26471874..26504484)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26252899..26285510)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234, member A Neighboring gene elongin-C-like Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42121 Neighboring gene STARR-positive B cell enhancer ABC_E5581 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:26389741-26389850 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene hemoglobin alpha, pseudogene 4 Neighboring gene predicted gene, 50015

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. Tufarelli C, et al. Genomics, 2001 Feb 1. PMID 11170747
    2. Serine-arginine-rich nuclear protein Luc7l regulates myogenesis in mice. Kimura E, et al. Gene, 2004 Oct 27. PMID 15474286
    3. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Cazalla D, et al. Mol Cell Biol, 2005 Apr. PMID 15798186, Free PMC Article
    4. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Blewitt ME, et al. Nat Genet, 2008 May. PMID 18425126
    5. Identification of differential protein interactors of lamin A and progerin. Kubben N, et al. Nucleus, 2010 Nov-Dec. PMID 21327095, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Luc7l is thought to play an important role in the regulation of muscle differentiation.
      Title: Serine-arginine-rich nuclear protein Luc7l regulates myogenesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RS domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splice site recognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative RNA-binding protein Luc7-like 1
    Names
    Luc7 homolog-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025881.3 → NP_080157.1  putative RNA-binding protein Luc7-like 1 isoform 1

      See identical proteins and their annotated locations for NP_080157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK010539, AK160293, BB771481
      Consensus CDS
      CCDS28550.1
      UniProtKB/TrEMBL
      A0A0R4J047, Q05D11
      Related
      ENSMUSP00000025023.8, ENSMUST00000025023.15
      Conserved Domains (1) summary
      pfam03194
      Location:5 → 231
      LUC7; LUC7 N_terminus

    2. NM_028190.3 → NP_082466.2  putative RNA-binding protein Luc7-like 1 isoform 2

      See identical proteins and their annotated locations for NP_082466.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, which results in an early stop codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC126438, AK160293, CF951283
      Consensus CDS
      CCDS28549.1
      UniProtKB/Swiss-Prot
      Q8K247, Q9CWM1, Q9CYI4
      UniProtKB/TrEMBL
      Q05D11
      Related
      ENSMUSP00000110627.3, ENSMUST00000114976.9
      Conserved Domains (1) summary
      pfam03194
      Location:5 → 242
      LUC7; LUC7 N_terminus

    RNA

    1. NR_037905.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC126438, BQ572015, BY726224
      Related
      ENSMUST00000148894.2

    2. NR_037906.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC126438
      Related
      ENSMUST00000133032.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26471874..26504484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317615.2 → XP_017173104.1  putative RNA-binding protein Luc7-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9CYI4
      Conserved Domains (1) summary
      pfam03194
      Location:1 → 178
      LUC7; LUC7 N_terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYI4.2 GenPept UniProtKB/Swiss-Prot:Q9CYI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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