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    Lgr4 Leucine-rich repeat-containing G protein-coupled receptor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lgr4provided by FlyBase
    Official Full Name
    Leucine-rich repeat-containing G protein-coupled receptor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0085440
    Locus tag
    Dmel_CG34411
    See related
    AllianceGenome:FB:FBgn0085440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.19; anon-WO0170980.20; CG32637; CG34411; CG4187; dLGR4; DLGR4; Dmel\CG34411; lgr4; LGR4
    Old locus tag
    CG32637; CG4187; Dmel_CG32637; Dmel_CG4187
    Summary
    Predicted to enable neuropeptide receptor activity and protein-hormone receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Malpighian tubule; adult brain; fat body; gut section; and salivary gland. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP1 (relaxin family peptide receptor 1) and RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lgr4 in Genome Data Viewer
    Location:
    11E1-11E3; 1-42 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13161714..13189164, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13055747..13083197, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Brahma associated protein 60kD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila. Miao H, et al. J Neurosci Res, 2024 Jan. PMID 38284837
    2. Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster. Van Hiel MB, et al. Peptides, 2015 Jun. PMID 25064813
    3. Genes involved in sex pheromone discrimination in Drosophila melanogaster and their background-dependent effect. Houot B, et al. PLoS One, 2012. PMID 22292044, Free PMC Article
    4. Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability. Colombani J, et al. Curr Biol, 2015 Oct 19. PMID 26441350
    5. Arthropod IGF, relaxin and gonadulin, putative orthologs of Drosophila insulin-like peptides 6, 7 and 8, likely originated from an ancient gene triplication. Veenstra JA. PeerJ, 2020. PMID 32728497, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila.
      Title: Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila.
    2. dLGR3 is expressed in the female fat body, while the expression of dLGR4 peaks in the midgut of both the wandering and adult stage.
      Title: Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein-hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich repeat-containing G protein-coupled receptor 4
    Names
    CG34411-PB
    CG34411-PC
    Lgr4-PB
    Lgr4-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13161714..13189164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298263.1 → NP_001285192.1  Leucine-rich repeat-containing G protein-coupled receptor 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E7BY71, X2JJX6
      Conserved Domains (6) summary
      cd00116
      Location:184 → 397
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:188 → 211
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:483 → 741
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam00057
      Location:87 → 124
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam12799
      Location:308 → 348
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:356 → 416
      LRR_8; Leucine rich repeat

    2. NM_001103496.2 → NP_001096966.2  Leucine-rich repeat-containing G protein-coupled receptor 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096966.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JSP6, E7BY71, Q0IGY0
      Conserved Domains (6) summary
      cd00116
      Location:181 → 394
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 208
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:480 → 738
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam00057
      Location:84 → 121
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam12799
      Location:305 → 345
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:353 → 413
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0IGY0 Q0IGY0
    Q5K354 Q5K354
    Q5K356 Q5K356
    Q5K357 Q5K357
    Q5K361 Q5K361
    X2JJX6 X2JJX6

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