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    Cpr11A Cuticular protein 11A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpr11Aprovided by FlyBase
    Official Full Name
    Cuticular protein 11Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030394
    Locus tag
    Dmel_CG2560
    See related
    AllianceGenome:FB:FBgn0030394
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2560; Dmel\CG2560; L12
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic ventral epidermis; and prothoracic gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpr11A in Genome Data Viewer
    Location:
    11A12-11A12; 1-38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12486970..12489448)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12381003..12383481)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rab40 Neighboring gene uncharacterized protein Neighboring gene Larval serum protein 1 alpha Neighboring gene Meckel syndrome, type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A corset function of exoskeletal ECM promotes body elongation in Drosophila. Tajiri R, et al. Commun Biol, 2021 Jan 19. PMID 33469125, Free PMC Article
    2. Notch signaling generates the "cut here line" on the cuticle of the puparium in Drosophila melanogaster. Tajiri R, et al. iScience, 2023 Aug 18. PMID 37529108, Free PMC Article
    3. Induced transcription results in local changes in chromatin structure, replication timing, and DNA polytenization in a site of intercalary heterochromatin. Koryakov DE, et al. Chromosoma, 2012 Dec. PMID 23015267
    4. Inhibition of fatty acid desaturation impairs cuticle differentiation in Drosophila melanogaster. Wang Y, et al. Arch Insect Biochem Physiol, 2019 Apr. PMID 30672604
    5. The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes. Weake VM, et al. BMC Mol Biol, 2007 May 19. PMID 17511883, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cuticular protein 11A
    Names
    CG2560-PA
    Cpr11A-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12486970..12489448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132575.3 → NP_572803.1  cuticular protein 11A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYM5
      Related
      FBpp0073483
      Conserved Domains (1) summary
      pfam00379
      Location:73 → 124
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYM5 Q9VYM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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