Inx2 Innexin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Inx2provided by FlyBase
Official Full Name: Innexin 2provided by FlyBase
Primary source: FLYBASE:FBgn0027108
Locus tag: Dmel_CG4590
See related: AllianceGenome:FB:FBgn0027108
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4590; D-inx-2; Dm-inx; Dm-inx2; Dm-Inx2; Dmel\CG4590; FBpp0291074; inx-2; Inx-2; INX-2; inx2; Ix2; kropf; l(1)G0035; l(1)G0036; l(1)G0043; l(1)G0059; l(1)G0118; l(1)G0157; l(1)G0317; l(1)G0364; prp33
Summary: Enables gap junction channel activity. Involved in several processes, including foregut morphogenesis; germarium-derived female germ-line cyst formation; and male germ-line stem cell population maintenance. Located in apical plasma membrane; apicolateral plasma membrane; and gap junction. Is expressed in several structures, including adult CNS glial cell; gut section; head epidermis primordium; somatic cell of ovariole; and somatic cell of testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 6E4-6E4; 1-18 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6998672..7004151)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6892705..6898184)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
Title: Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.
Integration of Migratory Cells into a New Site In Vivo Requires Channel-Independent Functions of Innexins on Microtubules.
Title: Integration of Migratory Cells into a New Site In Vivo Requires Channel-Independent Functions of Innexins on Microtubules.
Inx2 mediated calcium flux in the follicle cells stimulates endocytosis by altering Dynamin (Shibire) distribution which is critical for careful calibration of STAT activation and, thus for border cell specification.
Title: A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis.
inx2 is required for the transcriptional activation of dpp and punt in the eye disc.
Title: Drosophila eye size is determined by Innexin 2-dependent Decapentaplegic signalling.
Downregulation of either ogre or inx2 selectively in glia, by targeted expression of RNA interference transgenes, leads to a significant reduction in the size of the larval nervous system and behavioural defects in surviving adults.
Title: Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous system.
Data propose that Inx3 is a critical factor for dorsal closure and that it mediates the stability of Inx1, 2 and DE-cadherin by forming a complex.
Title: Innexin 3, a new gene required for dorsal closure in Drosophila embryo.
Innexin2 gap junctions in somatic support cells are required for cyst formation and for egg chamber formation in Drosophila.
Title: Innexin2 gap junctions in somatic support cells are required for cyst formation and for egg chamber formation in Drosophila.
innexin 2 is positioned apico-laterally as well as apically between follicle cells and germ-line cells. Innexin 2 is participating in cell-cell communication via hemichannels residing in the oolemma
Title: Gap junctions in the ovary of Drosophila melanogaster: localization of innexins 1, 2, 3 and 4 and evidence for intercellular communication via innexin-2 containing channels.
first study of cellular distribution and protein-protein interactions of an innexin gap junctional channel protein (inx2) in the developing epithelia of Drosophila
Title: Gap junction channel protein innexin 2 is essential for epithelial morphogenesis in the Drosophila embryo.
role of the innexin 2 and ogre genes during gastrointestinal development of the fly embryo
Title: Gastrointestinal development in the Drosophila embryo requires the activity of innexin gap junction channel proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	IC Inferred by Curator more info	PubMed
enables gap junction channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell communication	IDA Inferred from Direct Assay more info	PubMed
involved_in foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived female germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intercellular transport	IDA Inferred from Direct Assay more info	PubMed
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in gap junction	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info