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    Cyp4p1 Cytochrome P450 4p1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4p1provided by FlyBase
    Official Full Name
    Cytochrome P450 4p1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015037
    Locus tag
    Dmel_CG10842
    See related
    AllianceGenome:FB:FBgn0015037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4p1; anon-WO0140519.35; CG10842; Cyp4P1; CYP4p1; CYP4P1; Dmel\CG10842; P-450; P450
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; antenna; embryonic/larval Malpighian tubule; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4p1 in Genome Data Viewer
    Location:
    45B7-45B7; 2-60 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9240041..9242139)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5127546..5129644)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44451 Neighboring gene hikaru genki Neighboring gene Cytochrome P450 4p2 Neighboring gene Cytochrome P450 4p3 Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene Protein kinase N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions between detoxification mechanisms and excretion in Malpighian tubules of Drosophila melanogaster. Chahine S, et al. J Exp Biol, 2011 Feb 1. PMID 21228205
    2. Cytochrome P450s Cyp4p1 and Cyp4p2 associated with the DDT tolerance in the Drosophila melanogaster strain 91-R. Seong KM, et al. Pestic Biochem Physiol, 2019 Sep. PMID 31400775
    3. Identification and characterization of CYPs induced in the Drosophila antenna by exposure to a plant odorant. Baldwin SR, et al. Sci Rep, 2021 Oct 15. PMID 34654888, Free PMC Article
    4. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
    5. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh DP, et al. Experientia, 1992 Jan 15. PMID 1737575

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4p1
    Names
    CG10842-PA
    Cyp4p1-PA
    cytochrome P450
    cytochrome P450-4p1
    NP_524828.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9240041..9242139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080089.3 → NP_524828.1  cytochrome P450 4p1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24125, Q9V558
      Related
      FBpp0087673
      Conserved Domains (1) summary
      pfam00067
      Location:54 → 509
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V558.1 Q9V558

    Gene LinkOut

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    Other Literature Sources
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