Tie Tie-like receptor tyrosine kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tieprovided by FlyBase
Official Full Name: Tie-like receptor tyrosine kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0014073
Locus tag: Dmel_CG7525
See related: AllianceGenome:FB:FBgn0014073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7525; Dmel\CG7525; DPR1; RTK; tie
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in negative regulation of apoptotic signaling pathway; positive regulation of border follicle cell migration; and regulation of cellular response to X-ray. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in border follicle cell and centripetal follicle cell. Human ortholog(s) of this gene implicated in several diseases, including arteriovenous malformation; basal ganglia calcification; hematologic cancer (multiple); infantile myofibromatosis; and kidney cancer (multiple). Orthologous to human TEK (TEK receptor tyrosine kinase); PDGFRA (platelet derived growth factor receptor alpha); and PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64B9-64B9; 3-12 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4510698..4532145, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4510698..4532145, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Tie-like receptor tyrosine kinase

Names: CG7525-PA; Tie-PA; Tie-like receptor; tyrosine kinase; tyrosine kinase with Ig and epidermal growth factor homology domain

NP_523928.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4510698..4532145 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079204.2 → NP_523928.1 Tie-like receptor tyrosine kinase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523928.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24315, Q9VZA8

Related

FBpp0073179

Conserved Domains (2) summary

smart00219
Location:854 → 1183

TyrKc; Tyrosine kinase, catalytic domain

cd00192
Location:860 → 1187

PTKc; Catalytic domain of Protein Tyrosine Kinases