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    Hdc Histidine decarboxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36076, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Hdcprovided by FlyBase
    Official Full Name
    Histidine decarboxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005619
    Locus tag
    Dmel_CG3454
    See related
    AllianceGenome:FB:FBgn0005619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.259; CG3454; Dmel\CG3454; hdc; HDC; JK910
    Summary
    Enables histidine decarboxylase activity. Involved in thermotaxis. Predicted to be active in cytoplasm. Is expressed in adult brain cell body rind; adult head; adult ventral nerve cord; photoreceptor neurons; and retina. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Hdc in Genome Data Viewer
    Location:
    46F7-46F7; 2-62 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10237988..10246077)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6125493..6133582)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46322 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 3 Neighboring gene long non-coding RNA:CR45265 Neighboring gene uncharacterized protein Neighboring gene Chondroitin sulfate N-acetylgalactosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene Synaptobrevin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microsaccadic sampling of moving image information provides Drosophila hyperacute vision. Juusola M, et al. Elife, 2017 Sep 5. PMID 28870284, Free PMC Article
    2. Fly Photoreceptors Encode Phase Congruency. Friederich U, et al. PLoS One, 2016. PMID 27336733, Free PMC Article
    3. From fruit flies to barnacles, histamine is the neurotransmitter of arthropod photoreceptors. Stuart AE. Neuron, 1999 Mar. PMID 10197524
    4. Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis. Burg MG, et al. EMBO J, 1993 Mar. PMID 8096176, Free PMC Article
    5. Selective histamine uptake rescues photo- and mechanoreceptor function of histidine decarboxylase-deficient Drosophila mutant. Melzig J, et al. J Neurosci, 1998 Sep 15. PMID 9736639, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histidine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidine decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histidine decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in histamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histidine decarboxylase
    Names
    CG3454-PA
    CG3454-PB
    CG3454-PC
    CG3454-PD
    Hdc-PA
    Hdc-PB
    Hdc-PC
    Hdc-PD
    histidine-decarboxylase
    NP_001260855.1
    NP_001260856.1
    NP_001286274.1
    NP_523679.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10237988..10246077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299345.1 → NP_001286274.1  histidine decarboxylase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05733, Q9V5I3
      UniProtKB/TrEMBL
      B6IDW5, I0B8M2
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 413
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    2. NM_001273927.2 → NP_001260856.1  histidine decarboxylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260856.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEQ1
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 413
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    3. NM_001273926.1 → NP_001260855.1  histidine decarboxylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260855.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05733, Q9V5I3
      UniProtKB/TrEMBL
      B6IDW5, I0B8M2
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 413
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    4. NM_078955.3 → NP_523679.2  histidine decarboxylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523679.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05733, Q9V5I3
      UniProtKB/TrEMBL
      B6IDW5, I0B8M2
      Related
      FBpp0087422
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 413
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEQ1 A0A0B4KEQ1
    I0B8M2 I0B8M2
    Q05733.2 Q05733

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