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    Tubg2 tubulin, gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 103768, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tubg2provided by MGI
    Official Full Name
    tubulin, gamma 2provided by MGI
    Primary source
    MGI:MGI:2144208
    See related
    Ensembl:ENSMUSG00000045007 AllianceGenome:MGI:2144208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tubgl
    Summary
    Predicted to enable GTP binding activity and microtubule nucleator activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Located in cytoplasmic microtubule; pericentriolar material; and spindle microtubule. Is expressed in several structures, including epithelium; heart; nervous system; respiratory system; and tooth. Orthologous to human TUBG2 (tubulin gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 14.5), cortex adult (RPKM 14.3) and 25 other tissues See more
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    Genomic context

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    See Tubg2 in Genome Data Viewer
    Location:
    11 D; 11 64.3 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101045945..101052613)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101155874..101161787)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 Neighboring gene contactin associated protein-like 1 Neighboring gene C-C motif chemokine receptor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene knockout analysis of two gamma-tubulin isoforms in mice. Yuba-Kubo A, et al. Dev Biol, 2005 Jun 15. PMID 15893303
    2. Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte. Barrett SL, et al. Biol Reprod, 2007 Jun. PMID 17287496
    3. MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages. Eng EW, et al. Mol Biol Cell, 2007 Jul. PMID 17442887, Free PMC Article
    4. γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. Vinopal S, et al. PLoS One, 2012. PMID 22235350, Free PMC Article
    5. The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. Leonard PH, et al. BMC Dev Biol, 2015 May 29. PMID 26021315, Free PMC Article

    See all (193) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gamma-tubulin 2 is able to nucleate microtubules and substitute for gamma-tubulin 1
      Title: γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule nucleator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin ring complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin gamma-2 chain
    Names
    gamma-2-tubulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134028.2 → NP_598789.1  tubulin gamma-2 chain

      See identical proteins and their annotated locations for NP_598789.1

      Status: VALIDATED

      Source sequence(s)
      AL590969
      Consensus CDS
      CCDS25452.1
      UniProtKB/Swiss-Prot
      Q8VCK3
      UniProtKB/TrEMBL
      Q6F4J0
      Related
      ENSMUSP00000045901.10, ENSMUST00000043654.10
      Conserved Domains (1) summary
      cd02188
      Location:3 → 435
      gamma_tubulin; The gamma-tubulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101045945..101052613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531917.4 → XP_006531980.1  tubulin gamma-2 chain isoform X1

      Conserved Domains (1) summary
      cd02188
      Location:1 → 258
      gamma_tubulin; The gamma-tubulin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCK3.1 GenPept UniProtKB/Swiss-Prot:Q8VCK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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