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    Sh3beta Sh3beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sh3betaprovided by FlyBase
    Official Full Name
    Sh3betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035772
    Locus tag
    Dmel_CG8582
    See related
    AllianceGenome:FB:FBgn0035772
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8582; Dmel\CG8582; LD12912; SH3beta
    Summary
    Predicted to be active in cytoplasm. Is expressed in adult brain; adult brain cell body rind; adult heart; and organism. Orthologous to several human genes including SH3BGRL (SH3 domain binding glutamate rich protein like) and SH3BGRL2 (SH3 domain binding glutamate rich protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sh3beta in Genome Data Viewer
    Location:
    65F7-65F7; 3-20 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7364584..7369260, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7357684..7362360, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pastrel Neighboring gene antisense RNA:CR45835 Neighboring gene Secretory 63 Neighboring gene akirin Neighboring gene Sphingomyelin synthase related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. Grossman TR, et al. PLoS Genet, 2011 Nov. PMID 22072978, Free PMC Article
    2. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Ocorr K, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360457, Free PMC Article
    3. The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Akasaka T, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16882722, Free PMC Article
    4. Genes associated with honey bee behavioral maturation affect clock-dependent and -independent aspects of daily rhythmic activity in fruit flies. Fu C, et al. PLoS One, 2012. PMID 22606218, Free PMC Article
    5. The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning. Mohan M, et al. EMBO J, 2007 Oct 3. PMID 17805343, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sh3beta
    Names
    CG8582-PA
    CG8582-PB
    CG8582-PC
    CG8582-PD
    CG8582-PE
    Sh3beta-PA
    Sh3beta-PB
    Sh3beta-PC
    Sh3beta-PD
    Sh3beta-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7364584..7369260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202127.2 → NP_001189056.1  Sh3beta, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSK4
      Conserved Domains (1) summary
      cl00388
      Location:1 → 104
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_001202128.2 → NP_001189057.1  Sh3beta, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRQ6
      Conserved Domains (1) summary
      cl00388
      Location:1 → 104
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_168210.3 → NP_729248.1  Sh3beta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729248.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8H4, Q9NFP5, Q9VS58
      Related
      FBpp0076582
      Conserved Domains (1) summary
      pfam04908
      Location:1 → 104
      SH3BGR; SH3-binding, glutamic acid-rich protein

    4. NM_139855.4 → NP_648112.2  Sh3beta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648112.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8H4, Q9NFP5, Q9VS58
      Related
      FBpp0076583
      Conserved Domains (1) summary
      pfam04908
      Location:1 → 104
      SH3BGR; SH3-binding, glutamic acid-rich protein

    5. NM_001202126.1 → NP_001189055.1  Sh3beta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRR7
      Conserved Domains (1) summary
      cl00388
      Location:4 → 92
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRQ6 M9MRQ6
    M9MRR7 M9MRR7
    M9MSK4 M9MSK4
    Q9NFP5.2 Q9NFP5

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