U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ATPsynC ATP synthase, subunit C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43693, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ATPsynCprovided by FlyBase
    Official Full Name
    ATP synthase, subunit Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039830
    Locus tag
    Dmel_CG1746
    See related
    AllianceGenome:FB:FBgn0039830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey224; AT91; Atp5g1; ATP5MC3; CG1746; dATPsynC; Dmel\CG1746
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; gut section; and larval muscle cell. Used to study early-onset dystonia and/or spastic paraplegia and mitochondrial complex V (ATP synthase) deficiency. Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia; renal cell carcinoma; and urinary bladder cancer. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1); ATP5MC2 (ATP synthase membrane subunit c locus 2); and ATP5MC3 (ATP synthase membrane subunit c locus 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ATPsynC in Genome Data Viewer
    Location:
    100B7-100B7; 3-102 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31216145..31219630, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27041867..27045352, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene zwilch Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P RNA Neighboring gene mir-4949 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders. Lovero D, et al. PLoS One, 2018. PMID 30096161, Free PMC Article
    2. A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia. Neilson DE, et al. Mov Disord, 2022 Feb. PMID 34636445, Free PMC Article
    3. Transcriptional control of an essential ribozyme in Drosophila reveals an ancient evolutionary divide in animals. Manivannan SN, et al. PLoS Genet, 2015 Jan. PMID 25569672, Free PMC Article
    4. ATP synthase is required for male fertility and germ cell maturation in Drosophila testes. Yu J, et al. Mol Med Rep, 2019 Mar. PMID 30628672, Free PMC Article
    5. Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. Lieber T, et al. Nature, 2019 Jun. PMID 31092924, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP synthase, subunit C
    Names
    ATP synthase Lipid-binding protein P1
    ATP synthase lipid-binding protein
    ATPsynC-PA
    ATPsynC-PB
    ATPsynC-PC
    ATPsynC-PE
    ATPsynC-PG
    ATPsynthaseC
    CG1746-PA
    CG1746-PB
    CG1746-PC
    CG1746-PE
    CG1746-PG
    F0/F1 ATP synthase Lipid-binding protein
    complex Vc

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31216145..31219630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143595.2 → NP_651852.1  ATP synthase, subunit C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNC4, Q6NN09
      Related
      FBpp0085134
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 138
      ATP9; ATP synthase F0 subunit 9; Provisional

    2. NM_001260453.1 → NP_001247382.1  ATP synthase, subunit C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNC4, Q6NN09
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 138
      ATP9; ATP synthase F0 subunit 9; Provisional

    3. NM_170544.2 → NP_733423.1  ATP synthase, subunit C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNC4, Q6NN09
      Related
      FBpp0085135
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 138
      ATP9; ATP synthase F0 subunit 9; Provisional

    4. NM_170543.3 → NP_733422.1  ATP synthase, subunit C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNC4, Q6NN09
      Related
      FBpp0085136
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 138
      ATP9; ATP synthase F0 subunit 9; Provisional

    5. NM_001260455.2 → NP_001247384.1  ATP synthase, subunit C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H0RNC4, Q6NN09
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 138
      ATP9; ATP synthase F0 subunit 9; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H0RNC4 H0RNC4
    Q6NN09 Q6NN09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous