GILT1 Gamma-interferon-inducible lysosomal thiol reductase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GILT1provided by FlyBase
Official Full Name: Gamma-interferon-inducible lysosomal thiol reductase 1provided by FlyBase
Primary source: FLYBASE:FBgn0038149
Locus tag: Dmel_CG9796
See related: AllianceGenome:FB:FBgn0038149
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9796; Dmel\CG9796; GILT
Summary: Predicted to enable oxidoreductase activity, acting on a sulfur group of donors. Involved in positive regulation of defense response to bacterium. Located in plasma membrane. Is expressed in several structures, including adult brain cell body rind; epithelium; follicle cell; gut section; and synaptic neuropil domain. Orthologous to human IFI30 (IFI30 lysosomal thiol reductase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13398526..13401862, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9224248..9227584, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

gamma-interferon-inducible lysosomal thiol reductase (GILT)homologue, role in the innate immune response upon bacterial challenge
Title: Identification of gamma-interferon-inducible lysosomal thiol reductase (GILT) homologues in the fruit fly Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on a sulfur group of donors	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG9796-PA; GILT1-PA; Gamma-interferon-inducible lysosomal thiol reductase

NP_650287.3

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The following sections contain reference sequences that belong to a specific genome build. Explain