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    ATG8E AUTOPHAGY 8E [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819125, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATG8E
    Official Full Name
    AUTOPHAGY 8E
    Primary source
    TAIR:AT2G45170
    Locus tag
    AT2G45170
    See related
    Araport:AT2G45170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATATG8E; AUTOPHAGY 8E; T14P1.2
    Summary
    Involved in autophagy. Under nutrient starvation the protein localizes to autophagosomes.
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    Genomic context

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    See ATG8E in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (18624264..18625791)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene cytidinediphosphate diacylglycerol synthase 4 Neighboring gene GRAS family transcription factor Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Plant-specific transcription factor YABBY family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Anaerobic Product Ethanol Promotes Autophagy-Dependent Submergence Tolerance in Arabidopsis. Yuan LB, et al. Int J Mol Sci, 2020 Oct 5. PMID 33028029, Free PMC Article
    2. Visualization of autophagy in Arabidopsis using the fluorescent dye monodansylcadaverine and a GFP-AtATG8e fusion protein. Contento AL, et al. Plant J, 2005 May. PMID 15860017
    3. The Arabidopsis thaliana ACBP3 regulates leaf senescence by modulating phospholipid metabolism and ATG8 stability. Xiao S, et al. Autophagy, 2010 Aug. PMID 20574160
    4. Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation. Gao C, et al. Proc Natl Acad Sci U S A, 2015 Feb 10. PMID 25624505, Free PMC Article
    5. Overexpression of ATG8 in Arabidopsis Stimulates Autophagic Activity and Increases Nitrogen Remobilization Efficiency and Grain Filling. Chen Q, et al. Plant Cell Physiol, 2019 Feb 1. PMID 30407574

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study shows that the overexpression of ATG8 genes provides beneficial effects on N management at the whole-plant level without affecting yield or plant biomass.
      Title: Overexpression of ATG8 in Arabidopsis Stimulates Autophagic Activity and Increases Nitrogen Remobilization Efficiency and Grain Filling.
    2. A BAR-domain protein SH3P2, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation in Arabidopsis.
      Title: A BAR-domain protein SH3P2, which binds to phosphatidylinositol 3-phosphate and ATG8, regulates autophagosome formation in Arabidopsis.
    3. Study propose that SH3P2 functions together with DRP1A to convert the fused vesicles to tubular structures during cytokinesis.
      Title: SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation.
    4. ACBP3 is an important regulator of the ATG8- phosphatidylethanolamine (PE) complex via its interaction with PE. [ATG8e]
      Title: The Arabidopsis thaliana ACBP3 regulates leaf senescence by modulating phospholipid metabolism and ATG8 stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_130080.6
    NM_180100.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AUTOPHAGY 8E
    NP_182042.2
    • AUTOPHAGY 8E (ATG8E); CONTAINS InterPro DOMAIN/s: Light chain 3 (LC3) (InterPro:IPR004241); BEST Arabidopsis thaliana protein match is: Ubiquitin-like superfamily protein (TAIR:AT4G16520.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_850431.2
    • AUTOPHAGY 8E (ATATG8E); CONTAINS InterPro DOMAIN/s: Light chain 3 (LC3) (InterPro:IPR004241); BEST Arabidopsis thaliana protein match is: Ubiquitin-like superfamily protein (TAIR:AT4G16520.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18624264..18625791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130080.6 → NP_182042.2  AUTOPHAGY 8E [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182042.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S926, Q945K6
      UniProtKB/TrEMBL
      A0A178VZA0, A0A5S9X751
      Conserved Domains (1) summary
      cd16128
      Location:13 → 115
      Ubl_ATG8; ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae Atg8p and related proteins; sub-family of the autophagy-related 8 (ATG8) family

    2. NM_180100.7 → NP_850431.2  AUTOPHAGY 8E [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850431.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S926, Q945K6
      UniProtKB/TrEMBL
      A0A178VZA0, A0A5S9X751
      Conserved Domains (1) summary
      cd16128
      Location:13 → 115
      Ubl_ATG8; ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae Atg8p and related proteins; sub-family of the autophagy-related 8 (ATG8) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S926.2

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