AXR1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AXR1
Official Full Name: NAD(P)-binding Rossmann-fold superfamily protein
Primary source: TAIR:AT1G05180
Locus tag: AT1G05180
See related: Araport:AT1G05180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AUXIN RESISTANT 1; AUXIN RESISTANT PROTEIN 1; YUP8H12.21; YUP8H12_21
Summary: Encodes a subunit of the RUB1 activating enzyme that regulates the protein degradation activity of Skp1-Cullin-Fbox complexes, primarily, but not exclusively, affecting auxin responses. Acts alongside AS1 to exclude BP expression from leaves.
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Genomic context

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See AXR1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 14

Sequence:: Chromosome: 1; NC_003070.9 (1498114..1501953, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AXR1 modulates trichome morphogenesis through mediating ROP2 stability in Arabidopsis.
Title: AXR1 modulates trichome morphogenesis through mediating ROP2 stability in Arabidopsis.
AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization.
Title: AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization.
AXR1 and other neddylation enzymes are autoneddylated in an E2- and E3-independent manner in vitro and that AXR1 autoneddylation impairs NEDD8 E2 approximately thioester formation in the den1 mutant background in vivo.
Title: DENEDDYLASE1 Protein Counters Automodification of Neddylating Enzymes to Maintain NEDD8 Protein Homeostasis in Arabidopsis.
The fhy3 phenotypes of axillary bud outgrowth suppression and of stress-induced leaf growth retardation both required the AUXIN-RESISTANT1 gene, and are independent of phyA.
Title: FHY3 promotes shoot branching and stress tolerance in Arabidopsis in an AXR1-dependent manner.
The cytokinin resistance of axr1 seedlings is suppressed by loss of function of the type A ARR family member ARR5. AXR1 promotes the cytokinin response by facilitating type A ARR degradation.
Title: AXR1 promotes the Arabidopsis cytokinin response by facilitating ARR5 proteolysis.
SMAP1 is necessary for root meristem formation and normal embryo development in the axr1 background.
Title: SMALL ACIDIC PROTEIN1 acts with RUB modification components, the COP9 signalosome, and AXR1 to regulate growth and development of Arabidopsis.
AXR1 and AXL1 differ in ability to correct phenotypic defects in axr1-30, a severe loss-of-function AXR1 mutant, when the respective coding sequences are expressed from the same promoter, suggesting differential in vivo functions.
Title: AXR1-ECR1 and AXL1-ECR1 heterodimeric RUB-activating enzymes diverge in function in Arabidopsis thaliana.
Data show taht root hair cell-specific overexpression of the influx transporter AUXIN-RESISTANT1 enhanced root hair length.
Title: P-glycoprotein4 displays auxin efflux transporter-like action in Arabidopsis root hair cells and tobacco cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001035893.1

Supported by ESTs:

NM_100396.4

Supported by ESTs:

NM_202032.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NEDD8 activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like modifier activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auxin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular auxin homeostasis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within leaf morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cytokinin	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: NAD(P)-binding Rossmann-fold superfamily protein

NP_001030970.1

AUXIN RESISTANT 1 (AXR1); CONTAINS InterPro DOMAIN/s: Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: AXR1-like (TAIR:AT2G32410.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_172010.1

AUXIN RESISTANT 1 (AXR1); CONTAINS InterPro DOMAIN/s: Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: AXR1-like (TAIR:AT2G32410.1); Has 6539 Blast hits to 5902 proteins in 1375 species: Archae - 158; Bacteria - 2625; Metazoa - 1326; Fungi - 867; Plants - 442; Viruses - 0; Other Eukaryotes - 1121 (source: NCBI BLink).

NP_973761.1

AUXIN RESISTANT 1 (AXR1); CONTAINS InterPro DOMAIN/s: Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: AXR1-like (TAIR:AT2G32410.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

1498114..1501953 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100396.4 → NP_172010.1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172010.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42744

UniProtKB/TrEMBL

A0A178WFT2, A0A5S9SPU5, A0A654E8D0

Conserved Domains (1) summary

cd01493
Location:22 → 538

APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
NM_202032.2 → NP_973761.1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973761.1

Status: REVIEWED

UniProtKB/TrEMBL

F4I7A3

Conserved Domains (1) summary

cl22428
Location:21 → 434

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
NM_001035893.1 → NP_001030970.1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030970.1

Status: REVIEWED

UniProtKB/TrEMBL

F4I7A4

Conserved Domains (1) summary

cl22428
Location:21 → 300

E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...