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    CER1 Fatty acid hydroxylase superfamily [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837602, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CER1
    Official Full Name
    Fatty acid hydroxylase superfamily
    Primary source
    TAIR:AT1G02205
    Locus tag
    AT1G02205
    See related
    Araport:AT1G02205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT1G02200; CER22; ECERIFERUM 1; ECERIFERUM 22; POSSIBLE ALDEHYDE DECARBONYLASE; T6A9.16
    Summary
    Expression of the CER1 gene associated with production of stem epicuticular wax and pollen fertility. Biochemical studies showed that cer1 mutants are blocked in the conversion of stem wax C30 aldehydes to C29 alkanes, and they also lack the secondary alcohols and ketones. These suggested the CER1 protein is an aldehyde decarbonylase, but the exact molecular function of this protein remains to be determined.
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    Genomic context

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    See CER1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (418416..422579)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene metacaspase 1 Neighboring gene ferredoxin-like protein Neighboring gene Fatty acid hydroxylase superfamily Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene NAC (No Apical Meristem) domain transcriptional regulator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CER22 gene required for the synthesis of cuticular wax alkanes in Arabidopsis thaliana is allelic to CER1. Sakuradani E, et al. Planta, 2013 Mar. PMID 23117394
    2. Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses. Bourdenx B, et al. Plant Physiol, 2011 May. PMID 21386033, Free PMC Article
    3. The Arabidopsis cytochrome P450 enzyme CYP96A4 is involved in the wound-induced biosynthesis of cuticular wax and cutin monomers. Huang H, et al. Plant J, 2024 Jun. PMID 38456566
    4. Chrysotile asbestos and health in Zimbabwe: I. Analysis of miners and millers compensated for asbestos-related diseases since independence (1980). Cullen MR, et al. Am J Ind Med, 1991. PMID 1847001
    5. Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex. Bernard A, et al. Plant Cell, 2012 Jul. PMID 22773744, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CER1 controls alkane biosynthesis and is highly linked to responses to biotic and abiotic stresses.
      Title: Overexpression of Arabidopsis ECERIFERUM1 promotes wax very-long-chain alkane biosynthesis and influences plant response to biotic and abiotic stresses.
    2. Analyses of CER1 transcript levels, and stem cuticular wax load and composition in the cer1-6 (cer22) line indicated that cer1-6 is a weak mutant allele of CER1.
      Title: The CER22 gene required for the synthesis of cuticular wax alkanes in Arabidopsis thaliana is allelic to CER1.
    3. CER1 interacts with both CER3 and CYTB5 to catalyze the redox-dependent synthesis of very-long-chain (VLC) alkanes from VLC acyl-CoAs.
      Title: Reconstitution of plant alkane biosynthesis in yeast demonstrates that Arabidopsis ECERIFERUM1 and ECERIFERUM3 are core components of a very-long-chain alkane synthesis complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001197961.1
    NM_001331327.1
    NM_001331328.1
    NM_100101.4
    NM_180601.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aldehyde oxygenase (deformylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxygenase (deformylating) activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within aldehyde catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within alkane biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within alkane biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cutin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Fatty acid hydroxylase superfamily
    NP_001184890.1
    • ECERIFERUM 1 (CER1); FUNCTIONS IN: aldehyde decarbonylase activity; INVOLVED IN: aldehyde catabolic process, wax biosynthetic process, cuticle development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694), Uncharacterised protein, Wax2 C-terminal (InterPro:IPR021940); BEST Arabidopsis thaliana protein match is: Fatty acid hydroxylase superfamily (TAIR:AT1G02190.1).
    NP_171723.2
    • ECERIFERUM 1 (CER1); FUNCTIONS IN: aldehyde decarbonylase activity; INVOLVED IN: aldehyde catabolic process, wax biosynthetic process, cuticle development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694), Uncharacterised protein, Wax2 C-terminal (InterPro:IPR021940); BEST Arabidopsis thaliana protein match is: Fatty acid hydroxylase superfamily (TAIR:AT1G02190.1); Has 2658 Blast hits to 2653 proteins in 533 species: Archae - 0; Bacteria - 823; Metazoa - 248; Fungi - 388; Plants - 579; Viruses - 3; Other Eukaryotes - 617 (source: NCBI BLink).
    NP_850932.2
    • ECERIFERUM 1 (CER1); FUNCTIONS IN: aldehyde decarbonylase activity; INVOLVED IN: aldehyde catabolic process, wax biosynthetic process, cuticle development; LOCATED IN: endomembrane system, endoplasmic reticulum; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694), Uncharacterised protein, Wax2 C-terminal (InterPro:IPR021940); BEST Arabidopsis thaliana protein match is: Fatty acid hydroxylase superfamily (TAIR:AT1G02190.1); Has 341 Blast hits to 339 proteins in 49 species: Archae - 0; Bacteria - 44; Metazoa - 0; Fungi - 0; Plants - 284; Viruses - 0; Other Eukaryotes - 13 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      418416..422579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100101.4 → NP_171723.2  Fatty acid hydroxylase superfamily [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171723.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HVX9, F4HVY0, O22681, O23679, Q0WV76, Q39045
      UniProtKB/TrEMBL
      A0A178WGN0, A0A5S9S5V2
      Conserved Domains (1) summary
      PLN02869
      Location:1 → 624
      PLN02869; fatty aldehyde decarbonylase

    2. NM_001331327.1 → NP_001320548.1  Fatty acid hydroxylase superfamily [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AN85, A0A5S9S5V2

    3. NM_001197961.1 → NP_001184890.1  Fatty acid hydroxylase superfamily [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9S5V2
      Conserved Domains (3) summary
      PLN02869
      Location:1 → 629
      PLN02869; fatty aldehyde decarbonylase
      pfam04116
      Location:139 → 272
      FA_hydroxylase; Fatty acid hydroxylase superfamily
      pfam12076
      Location:451 → 624
      Wax2_C; WAX2 C-terminal domain

    4. NM_001331328.1 → NP_001320547.1  Fatty acid hydroxylase superfamily [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AN63, Q0WLZ2

    5. NM_180601.2 → NP_850932.2  Fatty acid hydroxylase superfamily [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850932.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0WLZ2
      Conserved Domains (2) summary
      pfam04116
      Location:4 → 108
      FA_hydroxylase; Fatty acid hydroxylase superfamily
      pfam12076
      Location:287 → 455
      Wax2_C; WAX2 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HVY0.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.