OGG1 8-oxoguanine-DNA glycosylase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: OGG1
Official Full Name: 8-oxoguanine-DNA glycosylase 1
Primary source: TAIR:AT1G21710
Locus tag: AT1G21710
See related: Araport:AT1G21710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 8-oxoguanine-DNA glycosylase 1; ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1; ATOGG1; F8K7.14; F8K7_14
Summary: Encodes 8-oxoguanine-DNA glycosylase. DNA repair enzyme.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP in downstream steps.
Title: Arabidopsis ZDP DNA 3'-phosphatase and ARP endonuclease function in 8-oxoG repair initiated by FPG and OGG1 DNA glycosylases.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
Title: Overexpression of AtOGG1, a DNA glycosylase/AP lyase, enhances seed longevity and abiotic stress tolerance in Arabidopsis.

Submit: New GeneRIF Correction

NM_102020.4

Function	Evidence Code	Pubs
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables oxidized purine nucleobase lesion DNA N-glycosylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

NP_173590.1

8-oxoguanine-DNA glycosylase 1 (OGG1); FUNCTIONS IN: oxidized purine base lesion DNA N-glycosylase activity; INVOLVED IN: DNA repair, base-excision repair; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Helix-hairpin-helix DNA-binding motif, class 1 (InterPro:IPR003583), Transcription factor TFIID, C-terminal/DNA glycosylase, N-terminal (InterPro:IPR012294), 8-oxoguanine DNA glycosylase, N-terminal (InterPro:IPR012904), HhH-GPD domain (InterPro:IPR003265); Has 951 Blast hits to 936 proteins in 417 species: Archae - 106; Bacteria - 332; Metazoa - 176; Fungi - 163; Plants - 46; Viruses - 0; Other Eukaryotes - 128 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain