MUM4 NAD-dependent epimerase/dehydratase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MUM4
Official Full Name: NAD-dependent epimerase/dehydratase family protein
Primary source: TAIR:AT1G53500
Locus tag: AT1G53500
See related: Araport:AT1G53500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA MUCILAGE-MODIFIED 4; ARABIDOPSIS THALIANA RHAMNOSE BIOSYNTHESIS 2; ATMUM4; ATRHM2; F22G10.13; MUCILAGE-MODIFIED 4; RHAMNOSE BIOSYNTHESIS 2; RHM2
Summary: encodes a putative NDP-L-rhamnose synthase, an enzyme required for the synthesis of the pectin rhamnogalacturonan I, the major component of Arabidopsis mucilage. Gene is involved in seed coat mucilage cell development. Mutant analyses suggest that MUM4 is required for complete mucilage synthesis, cytoplasmic rearrangement and seed coat development.
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Genomic context

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See MUM4 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (19966944..19969757, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis and Camelina sativa, and is regulated by the same transcription factor cascade as endogenous MUM4.
Title: Identification of a seed coat-specific promoter fragment from the Arabidopsis MUCILAGE-MODIFIED4 gene.
Transcription factor GL2 and RHM2 are critical for the biosynthesis of mucilage pectin.
Title: LASSO modeling of the Arabidopsis thaliana seed/seedling transcriptome: a model case for detection of novel mucilage and pectin metabolism genes.
A target of GL2 in the seed coat is the gene MUM4 and GL2 regulates seed oil production at least partly through its influence on MUM4 expression in the seed coat.
Title: Arabidopsis glabra2 mutant seeds deficient in mucilage biosynthesis produce more oil.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_104228.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity	TAS Traceable Author Statement more info	PubMed
enables UDP-4-keto-rhamnose-4-keto-reductase activity	TAS Traceable Author Statement more info	PubMed
enables UDP-L-rhamnose synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-L-rhamnose synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables UDP-glucose 4,6-dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables dTDP-glucose 4,6-dehydratase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within UDP-rhamnose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mucilage biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed coat development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: NAD-dependent epimerase/dehydratase family protein

NP_564633.2

MUCILAGE-MODIFIED 4 (MUM4); FUNCTIONS IN: UDP-4-keto-rhamnose-4-keto-reductase activity, UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity, catalytic activity, UDP-glucose 4,6-dehydratase activity, UDP-L-rhamnose synthase activity; INVOLVED IN: seed coat development, UDP-rhamnose biosynthetic process, mucilage biosynthetic process, metabolic process; LOCATED IN: soluble fraction; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), dTDP-4-dehydrorhamnose reductase (InterPro:IPR005913); BEST Arabidopsis thaliana protein match is: rhamnose biosynthesis 3 (TAIR:AT3G14790.1); Has 53909 Blast hits to 53717 proteins in 3029 species: Archae - 941; Bacteria - 31079; Metazoa - 1146; Fungi - 539; Plants - 1500; Viruses - 107; Other Eukaryotes - 18597 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

19966944..19969757 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104228.3 → NP_564633.2 NAD-dependent epimerase/dehydratase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564633.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LPG6

UniProtKB/TrEMBL

A0A178W591, A0A5S9WPC0, A0A5S9XDL2

Conserved Domains (1) summary

PLN02260
Location:3 → 667

PLN02260; probable rhamnose biosynthetic enzyme