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    PGM2 Phosphoglucomutase/phosphomannomutase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843410, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PGM2
    Official Full Name
    Phosphoglucomutase/phosphomannomutase family protein
    Primary source
    TAIR:AT1G70730
    Locus tag
    AT1G70730
    See related
    Araport:AT1G70730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5A18.9; F5A18_9; phosphoglucomutase 2
    Summary
    Encodes a cytosolic phosphoglucomutase (PGM). Two Arabidopsis PGM proteins (AT1G70730/PGM2 and AT1G23190/PGM3) have high sequence similarities and redundant functions. Mature plants possessing a single cPGM allele had a major reduction in cPGM activity. Whereas pgm2 and pgm3 single mutants are undistinguishable from the wild type, loss of both PGM2 and PGM3 severely impairs male and female gametophyte development.
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    Genomic context

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    See PGM2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (26668646..26673166, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene glycosyl hydrolase 9B1 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene myosin-binding protein (Protein of unknown function, DUF593)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of cytosolic phosphoglucomutase compromises gametophyte development in Arabidopsis. Egli B, et al. Plant Physiol, 2010 Dec. PMID 20959421, Free PMC Article
    2. Starch synthase 4 is located in the thylakoid membrane and interacts with plastoglobule-associated proteins in Arabidopsis. Gámez-Arjona FM, et al. Plant J, 2014 Oct. PMID 25088399
    3. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001160992.1
    NM_001160993.2
    NM_105741.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglucomutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoglucomutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gametophyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Phosphoglucomutase/phosphomannomutase family protein
    NP_001154464.1
    • Phosphoglucomutase/phosphomannomutase family protein; FUNCTIONS IN: intramolecular transferase activity, phosphotransferases, magnesium ion binding, phosphoglucomutase activity; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G23190.1); Has 6684 Blast hits to 6671 proteins in 2112 species: Archae - 92; Bacteria - 4940; Metazoa - 519; Fungi - 202; Plants - 162; Viruses - 0; Other Eukaryotes - 769 (source: NCBI BLink).
    NP_001154465.1
    • Phosphoglucomutase/phosphomannomutase family protein; FUNCTIONS IN: intramolecular transferase activity, phosphotransferases, magnesium ion binding, phosphoglucomutase activity; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G23190.1); Has 6668 Blast hits to 6655 proteins in 2105 species: Archae - 91; Bacteria - 4924; Metazoa - 519; Fungi - 202; Plants - 162; Viruses - 0; Other Eukaryotes - 770 (source: NCBI BLink).
    NP_177230.1
    • Phosphoglucomutase/phosphomannomutase family protein; FUNCTIONS IN: intramolecular transferase activity, phosphotransferases, magnesium ion binding, phosphoglucomutase activity; INVOLVED IN: response to cadmium ion, carbohydrate metabolic process; LOCATED IN: cytosol, nucleus, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G23190.1); Has 8013 Blast hits to 8000 proteins in 2264 species: Archae - 118; Bacteria - 6090; Metazoa - 518; Fungi - 215; Plants - 166; Viruses - 0; Other Eukaryotes - 906 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26668646..26673166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160993.2 → NP_001154465.1  Phosphoglucomutase/phosphomannomutase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154465.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W3C5, A0A5S9WT56, F4I6W4
      Conserved Domains (2) summary
      cd03085
      Location:86 → 662
      PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
      PLN02307
      Location:77 → 662
      PLN02307; phosphoglucomutase

    2. NM_105741.4 → NP_177230.1  Phosphoglucomutase/phosphomannomutase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177230.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SGC1
      UniProtKB/TrEMBL
      A0A178W3C5, A0A5S9WT56, A0A654EMU1, Q0WN31
      Conserved Domains (1) summary
      PLN02307
      Location:1 → 585
      PLN02307; phosphoglucomutase

    3. NM_001160992.1 → NP_001154464.1  Phosphoglucomutase/phosphomannomutase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154464.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W3C5, A0A5S9WT56, F4I6W3
      Conserved Domains (2) summary
      cd03085
      Location:29 → 605
      PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
      PLN02307
      Location:15 → 605
      PLN02307; phosphoglucomutase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SGC1.1

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