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    DGD1 UDP-Glycosyltransferase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820339, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DGD1
    Official Full Name
    UDP-Glycosyltransferase superfamily protein
    Primary source
    TAIR:AT3G11670
    Locus tag
    AT3G11670
    See related
    Araport:AT3G11670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DIGALACTOSYL DIACYLGLYCEROL DEFICIENT 1; DIGALACTOSYLDIACYLGLYCEROL SYNTHASE 1
    Summary
    Responsible for the final assembly of galactolipids in photosynthetic membranes. Provides stability to the PS I core complex (e.g. subunits PsaD, PsaE).
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    Genomic context

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    See DGD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (3680866..3684871, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NDR1/HIN1-like 2 Neighboring gene NDR1/HIN1-like 1 Neighboring gene miscRNA Neighboring gene aluminum activated malate transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Digalactosyldiacylglycerol Is Essential for Organization of the Membrane Structure in Etioplasts. Fujii S, et al. Plant Physiol, 2018 Aug. PMID 29946018, Free PMC Article
    2. Synthesis and transfer of galactolipids in the chloroplast envelope membranes of Arabidopsis thaliana. Kelly AA, et al. Proc Natl Acad Sci U S A, 2016 Sep 20. PMID 27601658, Free PMC Article
    3. Reduced Biosynthesis of Digalactosyldiacylglycerol, a Major Chloroplast Membrane Lipid, Leads to Oxylipin Overproduction and Phloem Cap Lignification in Arabidopsis. Lin YT, et al. Plant Cell, 2016 Jan. PMID 26721860, Free PMC Article
    4. Digalactosyl-diacylglycerol-deficiency lowers the thermal stability of thylakoid membranes. Krumova SB, et al. Photosynth Res, 2010 Sep. PMID 20645128, Free PMC Article
    5. Characterization of the Arabidopsis thermosensitive mutant atts02 reveals an important role for galactolipids in thermotolerance. Chen J, et al. Plant Cell Environ, 2006 Jul. PMID 17080965

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DGD1 synthesizes the bulk of digalactosyldiacylglycerol in etioplasts.
      Title: Digalactosyldiacylglycerol Is Essential for Organization of the Membrane Structure in Etioplasts.
    2. Different diglycosyllipid synthases (DGD1, DGD2, and Chloroflexus glucosyltransferase) were introduced into the dgd1-1 mutant of Arabidopsis in fusion with N-terminal extensions (NDGD1 and NDGD2) targeting to the outer envelope.NDGD1 binds to phosphatidic acid (PA) in membranes and mediates PA-dependent membrane fusion in vitro.
      Title: Synthesis and transfer of galactolipids in the chloroplast envelope membranes of Arabidopsis thaliana.
    3. At elevated temperatures MC540 is extruded from the dgd1 membrane bilayer around 35 degrees C, whereas in WT, it remains lipid-bound up to 45 degrees C and dgd1 and WT membranes become leaky around 35 and 45 degrees C, respectively.
      Title: Digalactosyl-diacylglycerol-deficiency lowers the thermal stability of thylakoid membranes.
    4. The roles of DGD1 and DGD1 SUPPRESSOR 1 (DGS1) in the expression of nuclear genes encoding enzymes of the alternative galactoglycerolipid pathway are reported.[DGS1]
      Title: Mutation of a mitochondrial outer membrane protein affects chloroplast lipid biosynthesis.
    5. The affected gene in atts02 was identified by positional cloning and encodes digalactosyldiacylglycerol synthase 1 (DGD1).
      Title: Characterization of the Arabidopsis thermosensitive mutant atts02 reveals an important role for galactolipids in thermotolerance.
    6. Data show that cold acclimation of the Arabidopsis dgd1 mutant results in recovery from photosystem I-limited photosynthesis.
      Title: Cold acclimation of the Arabidopsis dgd1 mutant results in recovery from photosystem I-limited photosynthesis.
    7. DGDG is important for the stability of the PSI complex.
      Title: Decreased stability of photosystem I in dgd1 mutant of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_111999.4
    NM_180230.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-galactosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables digalactosyldiacylglycerol synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactolipid galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within galactolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within oxylipin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photosystem I stabilization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    UDP-Glycosyltransferase superfamily protein
    NP_187773.1
    • DIGALACTOSYL DIACYLGLYCEROL DEFICIENT 1 (DGD1); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, group 1 (InterPro:IPR001296); BEST Arabidopsis thaliana protein match is: digalactosyl diacylglycerol deficient 2 (TAIR:AT4G00550.1); Has 287 Blast hits to 284 proteins in 72 species: Archae - 6; Bacteria - 66; Metazoa - 0; Fungi - 0; Plants - 156; Viruses - 0; Other Eukaryotes - 59 (source: NCBI BLink).
    NP_850561.1
    • DIGALACTOSYL DIACYLGLYCEROL DEFICIENT 1 (DGD1); BEST Arabidopsis thaliana protein match is: digalactosyl diacylglycerol deficient 2 (TAIR:AT4G00550.1); Has 183 Blast hits to 183 proteins in 35 species: Archae - 0; Bacteria - 6; Metazoa - 0; Fungi - 0; Plants - 152; Viruses - 0; Other Eukaryotes - 25 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3680866..3684871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111999.4 → NP_187773.1  UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EB81, Q9S7D1, W8PUU5
      UniProtKB/TrEMBL
      A0A178VKL1, A0A5S9XBG3, A0A654F7I9
      Conserved Domains (1) summary
      PLN02501
      Location:32 → 808
      PLN02501; digalactosyldiacylglycerol synthase

    2. NM_180230.1 → NP_850561.1  UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850561.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7D1
      Conserved Domains (2) summary
      PLN02501
      Location:32 → 639
      PLN02501; digalactosyldiacylglycerol synthase
      cl10013
      Location:343 → 638
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7D1.1

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