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    4CL5 4-coumarate:CoA ligase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821677, updated on 18-Sep-2024

    Summary

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    Official Symbol
    4CL5
    Official Full Name
    4-coumarate:CoA ligase 5
    Primary source
    TAIR:AT3G21230
    Locus tag
    AT3G21230
    See related
    Araport:AT3G21230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-coumarate:CoA ligase 5
    Summary
    The gene encodes a 4-coumarate coenzyme A ligase being able to use sinapate as substrate. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, 5-OH-ferulic acid, ferulic acid and sinapic acid. At4CL5 was unable to use cinnamic acid as substrate. Knockout of At4CL5 (4cl5) revealed no effect on syringyl lignin content indicating that the activity observed does probably not occur in vivo.
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    Genomic context

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    See 4CL5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (7448040..7452106, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene proton gradient regulation 7 Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene MAP kinase kinase 5 Neighboring gene 4-coumarate:CoA ligase 2 Neighboring gene multidrug resistance-associated protein 6 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization in vitro and in vivo of the putative multigene 4-coumarate:CoA ligase network in Arabidopsis: syringyl lignin and sinapate/sinapyl alcohol derivative formation. Costa MA, et al. Phytochemistry, 2005 Sep. PMID 16099486
    2. The 4-coumarate:CoA ligase gene family in Arabidopsis thaliana comprises one rare, sinapate-activating and three commonly occurring isoenzymes. Hamberger B, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14769935, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001338512.1
    NM_001338513.1
    NM_001338514.1
    NM_113018.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-coumarate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phenylpropanoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    4-coumarate:CoA ligase 5
    NP_188760.3
    • 4-coumarate:CoA ligase 5 (4CL5); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 86695 Blast hits to 79061 proteins in 3832 species: Archae - 1152; Bacteria - 55057; Metazoa - 3672; Fungi - 4648; Plants - 2823; Viruses - 1; Other Eukaryotes - 19342 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7448040..7452106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113018.4 → NP_188760.3  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188760.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84P22, Q8LPN8, Q9LU36
      UniProtKB/TrEMBL
      A0A654F9B2
      Conserved Domains (1) summary
      PLN02246
      Location:20 → 567
      PLN02246; 4-coumarate--CoA ligase

    2. NM_001338512.1 → NP_001326761.1  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQ96, A0A654F9B2

    3. NM_001338513.1 → NP_001326762.1  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQ97, A0A654F9B2

    4. NM_001338514.1 → NP_001326760.1  4-coumarate:CoA ligase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQ95
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LU36.1

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