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    HAT3.1 Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821485, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAT3.1
    Official Full Name
    Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain-containing protein
    Primary source
    TAIR:AT3G19510
    Locus tag
    AT3G19510
    See related
    Araport:AT3G19510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    Encodes a member of the PHD-finger homeodomain protein family. The HAT3.1 homeodomain is highly divergent in sequence even at positions that are almost invariable among homeodomains. HAT3.1 shows a preference for the sequence T(A/G)(A/C)ACCA, different from those bound by other homeodomains.
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    Genomic context

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    See HAT3.1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (6762761..6766597, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene complex 1 protein, LYR family protein Neighboring gene apoptosis inhibitor Neighboring gene hypothetical protein (DUF626) Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of the PHD-finger homeodomain protein HAT3.1 from Arabidopsis thaliana with DNA. Specific DNA binding by a homeodomain with histidine at position 51. Viola IL, et al. Biochemistry, 2007 Jun 26. PMID 17530779
    2. HAT3.1, a novel Arabidopsis homeodomain protein containing a conserved cysteine-rich region. Schindler U, et al. Plant J, 1993 Jul. PMID 8106082
    3. Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins. Halbach T, et al. Nucleic Acids Res, 2000 Sep 15. PMID 10982874, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of HAT3.1 with specific DNA binding by a homeodomain protein with histidine at position 51 was studied.
      Title: Interaction of the PHD-finger homeodomain protein HAT3.1 from Arabidopsis thaliana with DNA. Specific DNA binding by a homeodomain with histidine at position 51.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338403.1
    NM_112838.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain-containing protein
    NP_188582.1
    • HAT3.1; FUNCTIONS IN: sequence-specific DNA binding, DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of transcription, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: pathogenesis related homeodomain protein A (TAIR:AT4G29940.1); Has 21195 Blast hits to 13195 proteins in 937 species: Archae - 172; Bacteria - 5087; Metazoa - 6772; Fungi - 2621; Plants - 1255; Viruses - 207; Other Eukaryotes - 5081 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6762761..6766597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112838.4 → NP_188582.1  Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188582.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04996, Q8GZA9, Q9LT66
      UniProtKB/TrEMBL
      A0A5S9XDW2
      Conserved Domains (3) summary
      COG5576
      Location:576 → 695
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:622 → 666
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cd15504
      Location:267 → 319
      PHD_PRHA_like; PHD finger found in Arabidopsis thaliana pathogenesis-related homeodomain protein (PRHA) and similar proteins

    2. NM_001338403.1 → NP_001326497.1  Homeodomain-like protein with RING/FYVE/PHD-type zinc finger domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04996, Q8GZA9, Q9LT66
      UniProtKB/TrEMBL
      A0A5S9XDW2
      Conserved Domains (3) summary
      COG5576
      Location:576 → 695
      COG5576; Homeodomain-containing transcription factor [Transcription]
      cd00086
      Location:622 → 666
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      cd15504
      Location:267 → 319
      PHD_PRHA_like; PHD finger found in Arabidopsis thaliana pathogenesis-related homeodomain protein (PRHA) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04996.3

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