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    RBR1 retinoblastoma-related 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820408, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RBR1
    Official Full Name
    retinoblastoma-related 1
    Primary source
    TAIR:AT3G12280
    Locus tag
    AT3G12280
    See related
    Araport:AT3G12280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRBR1; RB; RB1; RBR; RETINOBLASTOMA 1; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-RELATED; retinoblastoma-related 1; RETINOBLASTOMA-RELATED PROTEIN 1
    Summary
    Encodes a retinoblastoma homologue RETINOBLASTOMA-RELATED protein (RBR or RBR1). RBR controls nuclear proliferation in the female gametophyte. Also required for correct differentiation of male gametophytic cell types. Regulates stem cell maintenance in Arabidopsis roots. Involved in the determination of cell cycle arrest in G1 phase after sucrose starvation. RBR1 is also involved in regulation of imprinted genes. Together with MSI1 it represses the expression of MET1. This in turn activates expression of the imprinted genes FIS2 and FWA. Functions as a positive regulator of the developmental switch from embryonic heterotrophic growth to autotrophic growth
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    Genomic context

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    See RBR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Sequence:
    Chromosome: 3; NC_003074.8 (3913349..3919359, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene TGACG motif-binding factor 6 Neighboring gene ncRNA Neighboring gene LYR family of Fe/S cluster biogenesis protein Neighboring gene ncRNA Neighboring gene protein arginine methyltransferase 3 Neighboring gene Amino acid dehydrogenase family protein Neighboring gene cilia/flagella-associated protein Neighboring gene uncharacterized protein Neighboring gene FKBP-like peptidyl-prolyl cis-trans isomerase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A dynamic reciprocal RBR-PRC2 regulatory circuit controls Arabidopsis gametophyte development. Johnston AJ, et al. Curr Biol, 2008 Nov 11. PMID 18976913
    2. Both negative and positive G1 cell cycle regulators undergo proteasome-dependent degradation during sucrose starvation in Arabidopsis. Hirano H, et al. Plant Signal Behav, 2011 Sep. PMID 22019639, Free PMC Article
    3. Distinct cell-autonomous functions of RETINOBLASTOMA-RELATED in Arabidopsis stem cells revealed by the Brother of Brainbow clonal analysis system. Wachsman G, et al. Plant Cell, 2011 Jul. PMID 21742994, Free PMC Article
    4. RETINOBLASTOMA-RELATED PROTEIN controls the transition to autotrophic plant development. Gutzat R, et al. Development, 2011 Jul. PMID 21693514
    5. Increased leaf mesophyll porosity following transient retinoblastoma-related protein silencing is revealed by microcomputed tomography imaging and leads to a system-level physiological response to the altered cell division pattern. Dorca-Fornell C, et al. Plant J, 2013 Dec. PMID 24118480, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dual role of the RETINOBLASTOMA-RELATED protein in the DNA damage response is coordinated by the interaction with LXCXE-containing proteins.
      Title: The dual role of the RETINOBLASTOMA-RELATED protein in the DNA damage response is coordinated by the interaction with LXCXE-containing proteins.
    2. The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex.
      Title: The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex.
    3. The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites.
      Title: The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites.
    4. ErbB-3 BINDING PROTEIN 1 Regulates Translation and Counteracts RETINOBLASTOMA RELATED to Maintain the Root Meristem.
      Title: ErbB-3 BINDING PROTEIN 1 Regulates Translation and Counteracts RETINOBLASTOMA RELATED to Maintain the Root Meristem.
    5. E2FB Interacts with RETINOBLASTOMA RELATED and Regulates Cell Proliferation during Leaf Development.
      Title: E2FB Interacts with RETINOBLASTOMA RELATED and Regulates Cell Proliferation during Leaf Development.
    6. Our analysis revealed binding of RBR1 to approximately 1000 genes and roughly 500 transposable elements. The RBR1-decorated genes broadly overlap with previously identified targets of two major transcription factors controlling the cell cycle.
      Title: Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators.
    7. XND1 harbors an apparently angiosperm-specific combination of interaction motifs potentially linking the general differentiation regulator RBR with a xylem-specific pathway for inhibition of differentiation.
      Title: XYLEM NAC DOMAIN1, an angiosperm NAC transcription factor, inhibits xylem differentiation through conserved motifs that interact with RETINOBLASTOMA-RELATED.
    8. One function of RBR1 is the direct repression of the stem cell factor WUSCHEL (WUS), which ectopically accumulates in meiocytes of triple krp and rbr1 mutants.
      Title: RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis.
    9. Together with E2FA, RBR is directly involved in the transcriptional DNA damage response as well as in the cell death pathway that is independent of SOG1, the plant functional analogue of p53.
      Title: Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control.
    10. The authors find that RBR1 is also required for RAD51 localization to DNA lesions.
      Title: The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202939.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription factor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double fertilization forming a zygote and endosperm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect endosperm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gametophyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within generative cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in guard cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase III IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in palisade mesophyll development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within trichome morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    retinoblastoma-related 1
    NP_001189868.1
    • retinoblastoma-related 1 (RBR1); FUNCTIONS IN: transcription factor binding; INVOLVED IN: in 15 processes; LOCATED IN: cytosol; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Retinoblastoma-associated protein, B-box (InterPro:IPR002719), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Retinoblastoma-associated protein, A-box (InterPro:IPR002720).
    NP_566417.3
    • retinoblastoma-related 1 (RBR1); FUNCTIONS IN: transcription factor binding; INVOLVED IN: in 15 processes; LOCATED IN: cytosol; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Retinoblastoma-associated protein, B-box (InterPro:IPR002719), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Retinoblastoma-associated protein, A-box (InterPro:IPR002720), Cyclin (InterPro:IPR006670); Has 676 Blast hits to 470 proteins in 118 species: Archae - 0; Bacteria - 0; Metazoa - 486; Fungi - 0; Plants - 147; Viruses - 0; Other Eukaryotes - 43 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3913349..3919359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112064.5 → NP_566417.3  retinoblastoma-related 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566417.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZS5, Q9C7C9, Q9LHH8, Q9LKZ3
      UniProtKB/TrEMBL
      A0A178VFS5, A0A5S9XBM0
      Conserved Domains (3) summary
      pfam01858
      Location:406 → 607
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:92 → 226
      DUF3452; Domain of unknown function (DUF3452)
      cd20601
      Location:730 → 861
      CYCLIN_AtRBR_like; cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar proteins

    2. NM_001202939.1 → NP_001189868.1  retinoblastoma-related 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VHJ9, A0A384KBH2, A0A5S9XBM0, F4J8Q4
      Conserved Domains (3) summary
      pfam01857
      Location:729 → 856
      RB_B; Retinoblastoma-associated protein B domain
      pfam01858
      Location:406 → 607
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:92 → 226
      DUF3452; Domain of unknown function (DUF3452)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LKZ3.1

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