U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cysteine proteinases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826792, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    Cysteine proteinases superfamily protein
    Primary source
    TAIR:AT4G01610
    Locus tag
    AT4G01610
    See related
    Araport:AT4G01610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T15B16.17; T15B16_17
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (694582..697206)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene GRAM domain family protein Neighboring gene expansin A17 Neighboring gene F-box associated ubiquitination effector family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities. Porodko A, et al. Biol Chem, 2018 Sep 25. PMID 29924726
    2. The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1. Iglesias-Fernández R, et al. J Exp Bot, 2014 May. PMID 24600022, Free PMC Article
    3. Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis. Ge Y, et al. Cell Death Differ, 2016 Sep 1. PMID 27058316, Free PMC Article
    4. Two proteases with caspase-3-like activity, cathepsin B and proteasome, antagonistically control ER-stress-induced programmed cell death in Arabidopsis. Cai YM, et al. New Phytol, 2018 May. PMID 28675441, Free PMC Article
    5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum-stress-induced programmed cell death is regulated positively by cathepsin B and negatively by PBA1, revealing a complex picture behind caspase-3-like activity in plants. Cathepsin B may execute its function after tonoplast rupture and works in parallel with VPE.[cathepsin B3]
      Title: Two proteases with caspase-3-like activity, cathepsin B and proteasome, antagonistically control ER-stress-induced programmed cell death in Arabidopsis.
    2. AtCathB2 and AtCathB3 are two closely related PLCPs which display subtle differences in their hydrolytic properties and substrate specificities. Both enzymes can act as endopeptidases and carboxydipeptidases.[CathB3]
      Title: The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities.
    3. Recombinant and native AtCathB3 had enzymatic activity against the synthetic caspase-3 substrate DEVD (Asp-Glu-Val-Asp) and were inhibited by synthetic caspase-3 inhibitors. cathepsin B does regulate PCD in both animal and plant cells suggesting that this protease may be part of an ancestral PCD pathway pre-existing the plant/animal divergence. [Cathepsin B3]
      Title: Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis.
    4. GBF1 is a transcriptional repressor of the AtCathB3 gene and affects germination kinetics of A. thaliana seeds. As AtCathB3 is also expressed during post-germination in cotyledons, a role for the AtCathB3-like protease in reserve mobilization is inferred.
      Title: The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    NM_116392.4
    NM_178950.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cysteine proteinases superfamily protein
    NP_567215.1
    • Cysteine proteinases superfamily protein; FUNCTIONS IN: cysteine-type endopeptidase activity, cysteine-type peptidase activity; INVOLVED IN: proteolysis, regulation of catalytic activity; LOCATED IN: vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Peptidase C1A, cathepsin B (InterPro:IPR015643), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Peptidase C1A, propeptide (InterPro:IPR012599); BEST Arabidopsis thaliana protein match is: Cysteine proteinases superfamily protein (TAIR:AT1G02305.1); Has 7486 Blast hits to 7443 proteins in 692 species: Archae - 63; Bacteria - 158; Metazoa - 3254; Fungi - 4; Plants - 1745; Viruses - 146; Other Eukaryotes - 2116 (source: NCBI BLink).
    NP_849281.1
    • Cysteine proteinases superfamily protein; FUNCTIONS IN: cysteine-type endopeptidase activity, cysteine-type peptidase activity; INVOLVED IN: proteolysis, regulation of catalytic activity; LOCATED IN: vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Peptidase C1A, cathepsin B (InterPro:IPR015643), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169), Peptidase C1A, propeptide (InterPro:IPR012599); BEST Arabidopsis thaliana protein match is: Cysteine proteinases superfamily protein (TAIR:AT1G02305.1); Has 7406 Blast hits to 7364 proteins in 687 species: Archae - 57; Bacteria - 153; Metazoa - 3244; Fungi - 4; Plants - 1710; Viruses - 146; Other Eukaryotes - 2092 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      694582..697206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116392.4 → NP_567215.1  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94K85, Q9ZSI0
      UniProtKB/TrEMBL
      A0A178UYV4
      Conserved Domains (2) summary
      cd02620
      Location:104 → 337
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:43 → 85
      Propeptide_C1; Peptidase family C1 propeptide

    2. NM_178950.2 → NP_849281.1  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XPB1, A0A654FL17
      Conserved Domains (2) summary
      cd02620
      Location:104 → 337
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:43 → 85
      Propeptide_C1; Peptidase family C1 propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94K85.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.