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    APR3 APS reductase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828288, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APR3
    Official Full Name
    APS reductase 3
    Primary source
    TAIR:AT4G21990
    Locus tag
    AT4G21990
    See related
    Araport:AT4G21990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    5'-ADENYLYLPHOSPHOSULFATE REDUCTASE; APS reductase 3; ATAPR3; F1N20.90; F1N20_90; PAPS REDUCTASE HOMOLOG 26; PRH-26; PRH26
    Summary
    Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. This protein also belongs to the adenosine 5'-phosphosulfate reductase-like (APRL) group.
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    Genomic context

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    See APR3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (11657008..11659167, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Peroxidase superfamily protein Neighboring gene senescence regulator (Protein of unknown function, DUF584) Neighboring gene Ubiquitin-like superfamily protein Neighboring gene tyrosine sulfotransferase-like protein Neighboring gene SKU5 similar 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutaredoxin function for the carboxyl-terminal domain of the plant-type 5'-adenylylsulfate reductase. Bick JA, et al. Proc Natl Acad Sci U S A, 1998 Jul 7. PMID 9653199, Free PMC Article
    2. Sulfate reduction in higher plants: molecular evidence for a novel 5'-adenylylsulfate reductase. Setya A, et al. Proc Natl Acad Sci U S A, 1996 Nov 12. PMID 8917600, Free PMC Article
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203866.1
    NM_118320.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenylyl-sulfate reductase (glutathione) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylyl-sulfate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within sulfate assimilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfate assimilation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    APS reductase 3
    NP_001190795.1
    • APS reductase 3 (APR3); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Phosphoadenosine phosphosulphate reductase (InterPro:IPR002500); BEST Arabidopsis thaliana protein match is: APS reductase 1 (TAIR:AT4G04610.1).
    NP_193930.1
    • APS reductase 3 (APR3); FUNCTIONS IN: adenylyl-sulfate reductase activity; INVOLVED IN: sulfate assimilation; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Thioredoxin-independent 5'-adenylylsulphate reductase (InterPro:IPR004508), Thioredoxin fold (InterPro:IPR012335), Phosphoadenosine phosphosulphate reductase (InterPro:IPR002500), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: APS reductase 1 (TAIR:AT4G04610.1); Has 5608 Blast hits to 5124 proteins in 1636 species: Archae - 157; Bacteria - 2658; Metazoa - 1176; Fungi - 493; Plants - 493; Viruses - 0; Other Eukaryotes - 631 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11657008..11659167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203866.1 → NP_001190795.1  APS reductase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JKD5
      Conserved Domains (1) summary
      PRK02090
      Location:118 → 339
      PRK02090; phosphoadenosine phosphosulfate reductase; Provisional

    2. NM_118320.3 → NP_193930.1  APS reductase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2S3, O48887, P92980, Q38948, Q8LAV2
      UniProtKB/TrEMBL
      A0A178V3H2, A0A5S9XUN1, A0A654FRL7
      Conserved Domains (3) summary
      PLN02309
      Location:24 → 458
      PLN02309; 5'-adenylylsulfate reductase
      PRK02090
      Location:83 → 322
      PRK02090; phosphoadenosine phosphosulfate reductase; Provisional
      cd02993
      Location:346 → 454
      PDI_a_APS_reductase; PDIa family, 5'-Adenylylsulfate (APS) reductase subfamily; composed of plant-type APS reductases containing a C-terminal redox active TRX domain and an N-terminal reductase domain which is part of a superfamily that includes N type ATP PPases. APS ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92980.2

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