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    CHLM magnesium-protoporphyrin IX methyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828611, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CHLM
    Official Full Name
    magnesium-protoporphyrin IX methyltransferase
    Primary source
    TAIR:AT4G25080
    Locus tag
    AT4G25080
    See related
    Araport:AT4G25080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F24A6.6; magnesium-protoporphyrin IX methyltransferase; MGPIXMT
    Summary
    Encodes a protein with methyltransferase activity responsible for the methylation of magnesium protoporphyrin IX. Mutants defective in this gene are affected in chlorophyll biosynthesis and show a reduction in the accumulation of a number of major thylakoid-associated proteins including components of PSI (LHCI), PSII (LHCII, D1, CP43) and the cytochrome b6f complex (Cytf). By contrast, no significant changes were detected for the proteins of the stroma and the chloroplast envelope.
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    Genomic context

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    See CHLM in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (12876822..12878703)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene acyl carrier protein 4 Neighboring gene caldesmon-like protein Neighboring gene Riboflavin synthase-like superfamily protein Neighboring gene Fe superoxide dismutase 1 Neighboring gene metacaspase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Mg-Protoporphyrin IX Methyltransferase Activity and Redox Regulation Depend on Conserved Cysteines. Richter AS, et al. Plant Cell Physiol, 2016 Mar. PMID 26759408
    2. The plant S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase is located in both envelope and thylakoid chloroplast membranes. Block MA, et al. Eur J Biochem, 2002 Jan. PMID 11784318
    3. Mg-chelatase I subunit 1 and Mg-protoporphyrin IX methyltransferase affect the stomatal aperture in Arabidopsis thaliana. Tomiyama M, et al. J Plant Res, 2014 Jul. PMID 24840863, Free PMC Article
    4. C1 metabolism and chlorophyll synthesis: the Mg-protoporphyrin IX methyltransferase activity is dependent on the folate status. Van Wilder V, et al. New Phytol, 2009. PMID 19076298
    5. Knock-out of the magnesium protoporphyrin IX methyltransferase gene in Arabidopsis. Effects on chloroplast development and on chloroplast-to-nucleus signaling. Pontier D, et al. J Biol Chem, 2007 Jan 26. PMID 17135235, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The modified CHLM activity of single and double mutants with cysteine substitution is presented, and the role of each cysteine residue is discussed based on a modeled structure of CHLM.
      Title: Arabidopsis Mg-Protoporphyrin IX Methyltransferase Activity and Redox Regulation Depend on Conserved Cysteines.
    2. The chlorophyll synthesis enzymes, Mg-chelatase complex and Mg-protoporphyrin IX methyltransferase, specifically affect abscisic acid (ABA) signaling in the control of stomatal aperture and have no effect on ABA-induced gene expression.
      Title: Mg-chelatase I subunit 1 and Mg-protoporphyrin IX methyltransferase affect the stomatal aperture in Arabidopsis thaliana.
    3. The decrease of the methylation index reduced by a factor of 3 the activity of the Mg-protoporphyrin IX methyltransferase (CHLM), an essential enzyme for chlorophyll synthesis.
      Title: C1 metabolism and chlorophyll synthesis: the Mg-protoporphyrin IX methyltransferase activity is dependent on the folate status.
    4. is essential for the formation of chlorophyll and subsequently for the formation of photosystems I and II and cytochrome b6f complexes
      Title: Knock-out of the magnesium protoporphyrin IX methyltransferase gene in Arabidopsis. Effects on chloroplast development and on chloroplast-to-nucleus signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125580.1
    NM_001203903.1
    NM_118640.3
    NM_179107.2
    NM_179108.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables magnesium protoporphyrin IX methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium protoporphyrin IX methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium protoporphyrin IX methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chlorophyll biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    magnesium-protoporphyrin IX methyltransferase
    NP_001119052.1
    • magnesium-protoporphyrin IX methyltransferase (CHLM); FUNCTIONS IN: magnesium protoporphyrin IX methyltransferase activity; INVOLVED IN: chlorophyll biosynthetic process; LOCATED IN: chloroplast thylakoid membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Magnesium protoporphyrin O-methyltransferase (InterPro:IPR010251), Magnesium-protoporphyrin IX methyltransferase, C-terminal (InterPro:IPR010940); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001190832.1
    • magnesium-protoporphyrin IX methyltransferase (CHLM); CONTAINS InterPro DOMAIN/s: Magnesium-protoporphyrin IX methyltransferase, C-terminal (InterPro:IPR010940), Magnesium protoporphyrin O-methyltransferase (InterPro:IPR010251).
    NP_194238.1
    • magnesium-protoporphyrin IX methyltransferase (CHLM); FUNCTIONS IN: magnesium protoporphyrin IX methyltransferase activity; INVOLVED IN: chlorophyll biosynthetic process; LOCATED IN: chloroplast thylakoid membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Magnesium-protoporphyrin IX methyltransferase, C-terminal (InterPro:IPR010940), Magnesium protoporphyrin O-methyltransferase (InterPro:IPR010251); Has 3281 Blast hits to 3281 proteins in 1119 species: Archae - 36; Bacteria - 2263; Metazoa - 32; Fungi - 20; Plants - 76; Viruses - 0; Other Eukaryotes - 854 (source: NCBI BLink).
    NP_849438.1
    • magnesium-protoporphyrin IX methyltransferase (CHLM); FUNCTIONS IN: magnesium protoporphyrin IX methyltransferase activity; INVOLVED IN: chlorophyll biosynthetic process; LOCATED IN: chloroplast thylakoid membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Magnesium-protoporphyrin IX methyltransferase, C-terminal (InterPro:IPR010940), Magnesium protoporphyrin O-methyltransferase (InterPro:IPR010251); Has 3281 Blast hits to 3281 proteins in 1119 species: Archae - 36; Bacteria - 2263; Metazoa - 32; Fungi - 20; Plants - 76; Viruses - 0; Other Eukaryotes - 854 (source: NCBI BLink).
    NP_849439.1
    • magnesium-protoporphyrin IX methyltransferase (CHLM); FUNCTIONS IN: magnesium protoporphyrin IX methyltransferase activity; INVOLVED IN: chlorophyll biosynthetic process; LOCATED IN: chloroplast thylakoid membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Magnesium-protoporphyrin IX methyltransferase, C-terminal (InterPro:IPR010940), Magnesium protoporphyrin O-methyltransferase (InterPro:IPR010251); Has 3281 Blast hits to 3281 proteins in 1119 species: Archae - 36; Bacteria - 2263; Metazoa - 32; Fungi - 20; Plants - 76; Viruses - 0; Other Eukaryotes - 854 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12876822..12878703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341721.1 → NP_001328344.1  magnesium-protoporphyrin IX methyltransferase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4G1

    2. NM_001203903.1 → NP_001190832.1  magnesium-protoporphyrin IX methyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190832.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4K6, B9DF98, Q9SW18
      UniProtKB/TrEMBL
      A0A178V3C5, A0A5S9XVR1
      Conserved Domains (1) summary
      PLN02585
      Location:1 → 312
      PLN02585; magnesium protoporphyrin IX methyltransferase

    3. NM_179108.3 → NP_849439.1  magnesium-protoporphyrin IX methyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849439.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4K6, B9DF98, Q9SW18
      UniProtKB/TrEMBL
      A0A178V3C5, A0A5S9XVR1
      Conserved Domains (1) summary
      PLN02585
      Location:1 → 312
      PLN02585; magnesium protoporphyrin IX methyltransferase

    4. NM_118640.3 → NP_194238.1  magnesium-protoporphyrin IX methyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194238.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4K6, B9DF98, Q9SW18
      UniProtKB/TrEMBL
      A0A178V3C5, A0A5S9XVR1
      Conserved Domains (1) summary
      PLN02585
      Location:1 → 312
      PLN02585; magnesium protoporphyrin IX methyltransferase

    5. NM_179107.2 → NP_849438.1  magnesium-protoporphyrin IX methyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849438.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4K6, B9DF98, Q9SW18
      UniProtKB/TrEMBL
      A0A178V3C5, A0A5S9XVR1
      Conserved Domains (1) summary
      PLN02585
      Location:1 → 312
      PLN02585; magnesium protoporphyrin IX methyltransferase

    6. NM_001125580.1 → NP_001119052.1  magnesium-protoporphyrin IX methyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SW18
      Conserved Domains (2) summary
      PRK07580
      Location:22 → 244
      PRK07580; Mg-protoporphyrin IX methyl transferase; Validated
      TIGR02021
      Location:22 → 242
      BchM-ChlM; magnesium protoporphyrin O-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SW18.1

    Gene LinkOut

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