CBF2 C-repeat/DRE binding factor 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CBF2
Official Full Name: C-repeat/DRE binding factor 2
Primary source: TAIR:AT4G25470
Locus tag: AT4G25470
See related: Araport:AT4G25470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCBF2; C-repeat/DRE binding factor 2; DRE/CRT-BINDING PROTEIN; DRE/CRT-BINDING PROTEIN 1C; DREB1C; FREEZING TOLERANCE QTL 4; FTQ4; T30C3.12
Summary: Encodes a member of the DREB subfamily A-1 of ERF/AP2 transcription factor family (CBF2). The protein contains one AP2 domain. There are six members in this subfamily, including CBF1, CBF2, and CBF3. This gene is involved in response to low temperature, abscisic acid, and circadian rhythm. Overexpressing this gene leads to increased freeze tolerance and induces the expression level of 85 cold-induced genes and reduces the expression level of 8 cold-repressed genes, which constitute the CBF2 regulon. Mutations in CBF2 increases the expression level of CBF1 and CBF3, suggesting that this gene may be involved in a negative regulatory or feedback circuit of the CBF pathway.
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Genomic context

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See CBF2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (13015250..13016235, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Divergence in Orthologous Transcription Factors: Insights from AtCBF2/3/1 and OsDREB1C.
Title: Functional Divergence in Orthologous Transcription Factors: Insights from AtCBF2/3/1 and OsDREB1C.
Genotype-dependent contribution of CBF transcription factors to long-term acclimation to high light and cool temperature.
Title: Genotype-dependent contribution of CBF transcription factors to long-term acclimation to high light and cool temperature.
The direct targets of CBFs: In cold stress response and beyond.
Title: The direct targets of CBFs: In cold stress response and beyond.
Here we present results establishing that the difference in CBF2 alleles contributes to the difference in freezing tolerance between two ecotypes.
Title: CBF-dependent and CBF-independent regulatory pathways contribute to the differences in freezing tolerance and cold-regulated gene expression of two Arabidopsis ecotypes locally adapted to sites in Sweden and Italy.
This study reveals the essential functions of C-repeat binding factors (CBF) in chilling stress response and cold acclimation, as well as defines a set of genes as CBF regulon.
Title: The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis.
CBFs play an important role in the trade-off between cold tolerance and plant growth through the precise regulation of COR genes in the complicated transcriptional network.
Title: The precise regulation of different COR genes by individual CBF transcription factors in Arabidopsis thaliana.
the three CBF genes together are required for cold acclimation and freezing tolerance.
Title: Mutational Evidence for the Critical Role of CBF Transcription Factors in Cold Acclimation in Arabidopsis.
RDM4 is important for Pol II occupancy at the promoters of CBF2 and CBF3.
Title: RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway.
Data indicate that the C-repeat binding factor (CBF) locus includes three genes - CBF1, CBF2 and CBF3 (AT4G25480) - that are induced by low temperature and encode transcription factors.
Title: Natural variation in the C-repeat binding factor cold response pathway correlates with local adaptation of Arabidopsis ecotypes.
A major locus harboring three cold-responsive transcription factor genes CBF1, was identified.
Title: Natural variation of C-repeat-binding factor (CBFs) genes is a major cause of divergence in freezing tolerance among a group of Arabidopsis thaliana populations along the Yangtze River in China.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_118679.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: C-repeat/DRE binding factor 2

NP_567719.1

C-repeat/DRE binding factor 2 (CBF2); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: C-repeat/DRE binding factor 1 (TAIR:AT4G25490.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13015250..13016235 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118679.2 → NP_567719.1 C-repeat/DRE binding factor 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567719.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65613, O82776, Q08A88, Q5QE69, Q9SYS6

UniProtKB/TrEMBL

A0A5S9XVV2, A0A654FSM9, B2BIW1, B2BIW9, B2BIX7

Conserved Domains (1) summary

cd00018
Location:49 → 109

AP2; DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor ...