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    HMA3 heavy metal atpase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829135, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMA3
    Official Full Name
    heavy metal atpase 3
    Primary source
    TAIR:AT4G30120
    Locus tag
    AT4G30120
    See related
    Araport:AT4G30120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. THALIANA HEAVY METAL ATPASE 3; ATHMA3; F6G3.150; F6G3_150; heavy metal atpase 3
    Summary
    encodes a protein similar to Zn-ATPase, a P1B-type ATPases transport zinc
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    Genomic context

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    See HMA3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (14730215..14733628, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene heavy metal atpase 2 Neighboring gene DUF630 family protein (DUF630 and DUF632) Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene Urb2/Npa2 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural variation in leaf cadmium in Arabidopsis thaliana. Chao DY, et al. PLoS Genet, 2012 Sep. PMID 22969436, Free PMC Article
    2. AtHMA3, a P1B-ATPase allowing Cd/Zn/Co/Pb vacuolar storage in Arabidopsis. Morel M, et al. Plant Physiol, 2009 Feb. PMID 19036834, Free PMC Article
    3. Purification of low-abundance Arabidopsis plasma-membrane protein complexes and identification of candidate components. Qi Y, et al. Plant J, 2009 Mar. PMID 19000159
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341994.1
    NM_119158.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heavy metal atpase 3
    NP_194741.2
    • heavy metal atpase 3 (HMA3); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: ATP biosynthetic process, metal ion transport; LOCATED IN: membrane; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: heavy metal atpase 2 (TAIR:AT4G30110.1); Has 27689 Blast hits to 27671 proteins in 2971 species: Archae - 638; Bacteria - 20543; Metazoa - 1641; Fungi - 1310; Plants - 1204; Viruses - 3; Other Eukaryotes - 2350 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14730215..14733628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119158.4 → NP_194741.2  heavy metal atpase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194741.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0CW77, Q1PE33, Q8LPW0, Q9LCZ8, Q9SZW5
      UniProtKB/TrEMBL
      A0MFB1
      Conserved Domains (2) summary
      COG2608
      Location:16 → 74
      CopZ; Copper chaperone CopZ [Inorganic ion transport and metabolism]
      pfam00122
      Location:167 → 386
      E1-E2_ATPase; E1-E2 ATPase

    2. NM_001341994.1 → NP_001328455.1  heavy metal atpase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4Q4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CW77.1

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