U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PTR1 peptide transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824581, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PTR1
    Official Full Name
    peptide transporter 1
    Primary source
    TAIR:AT3G54140
    Locus tag
    AT3G54140
    See related
    Araport:AT3G54140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PEPTIDE TRANSPORTER 1; AtNPF8.1; ATPTR1; NPF8.1; NRT1/ PTR family 8.1; peptide transporter 1
    Summary
    Encodes a di- and tri-peptide transporter that recognizes a variety of different amino acid combinations. GFP-tagged PTR1 localizes to the plasma membrane and has 8 to 11 predicted transmembrane domains. PTR1 is expressed in a number of different vascular tissues throughout the plant based on promoter:GUS expression analysis. ptr1 mutants have a lower dry weight than wild type plants when both are grown with Pro-Ala or Ala-Ala dipeptides as their nitrogen source, suggesting that PTR1 plays a role in dipeptide uptake in the roots. Furthermore N content of ptr1 mutants is lower than that of wild type plants when grown with Pro-Ala or a mixture of dipeptides as nitrogen source
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PTR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (20045603..20048745, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plant uncoupling mitochondrial protein 1 Neighboring gene Reticulon family protein Neighboring gene Josephin family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene RNI-like superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. AtPTR1, a plasma membrane peptide transporter expressed during seed germination and in vascular tissue of Arabidopsis. Dietrich D, et al. Plant J, 2004 Nov. PMID 15500465
    2. Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5. Hammes UZ, et al. J Biol Chem, 2010 Dec 17. PMID 20937801, Free PMC Article
    3. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5
      Title: Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5.
    2. A new transporter mediating the uptake of di- and tripeptides was isolated from Arabidopsis thaliana. [AtPTR1]
      Title: AtPTR1, a plasma membrane peptide transporter expressed during seed germination and in vascular tissue of Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001339651.1
    NM_115274.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptide transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables tripeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within dipeptide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tripeptide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    peptide transporter 1
    NP_190982.1
    • peptide transporter 1 (PTR1); FUNCTIONS IN: dipeptide transporter activity, tripeptide transporter activity, transporter activity; INVOLVED IN: dipeptide transport, oligopeptide transport, nitrogen compound metabolic process, tripeptide transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 40 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: PTR2 family proton/oligopeptide symporter, conserved site (InterPro:IPR018456), Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: peptide transporter 5 (TAIR:AT5G01180.1); Has 8339 Blast hits to 7886 proteins in 1502 species: Archae - 0; Bacteria - 4164; Metazoa - 798; Fungi - 498; Plants - 2234; Viruses - 0; Other Eukaryotes - 645 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20045603..20048745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115274.3 → NP_190982.1  peptide transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190982.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M390
      UniProtKB/TrEMBL
      A0A178VD50, A0A5S9XKP7
      Conserved Domains (1) summary
      cd17418
      Location:28 → 561
      MFS_NPF8; NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters

    2. NM_001339651.1 → NP_001326764.1  peptide transporter 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M390
      UniProtKB/TrEMBL
      A0A178VD50, A0A5S9XKP7
      Conserved Domains (1) summary
      cd17418
      Location:28 → 561
      MFS_NPF8; NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M390.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools